MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN
Noroviruses are the main cause for acute gastroenteritis disease. They infect the host cell via interaction with HGBA receptors on the cell surface. Virus makes complex with cell surface receptors through its capsid protein VP1 to enter the cell. Although the protein has been successfully crystalliz...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Trakya University
2019-04-01
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| Series: | Trakya University Journal of Natural Sciences |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/637369 |
| _version_ | 1797633887499714560 |
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| author | Abdulkadir Kocak Müslüm Yıldız |
| author_facet | Abdulkadir Kocak Müslüm Yıldız |
| author_sort | Abdulkadir Kocak |
| collection | DOAJ |
| description | Noroviruses are the main cause for acute gastroenteritis disease. They
infect the host cell via interaction with HGBA receptors on the cell surface. Virus makes complex
with cell surface receptors through its capsid protein VP1 to enter the cell.
Although the protein has been successfully crystallized in the presence of some
common glycans, the dynamic change in the protein structure when interacting
with sugar moieties has yet to be fully elucidated. This is critically
important since it leads to understanding the protein’s recognition mechanism of
HBGAs and develop therapeutic strategies against the gastroenteritis disease.
Here, we computationally assessed the dynamic features of wild type VP1
envelope protein to get insights into the interactions that can be important
for virus infectivity. We have found that the binding of sugar moiety does not
cause noticeable dynamic changes in the binding region. However, interestingly,
a drastic change occurs in a distant loop lying at the residue numbers of
395-400, which might be indication of an allosteric effect. |
| first_indexed | 2024-03-11T11:59:54Z |
| format | Article |
| id | doaj.art-a3ba01d5a17745349b0165dd796eee8a |
| institution | Directory Open Access Journal |
| issn | 2528-9691 |
| language | English |
| last_indexed | 2024-03-11T11:59:54Z |
| publishDate | 2019-04-01 |
| publisher | Trakya University |
| record_format | Article |
| series | Trakya University Journal of Natural Sciences |
| spelling | doaj.art-a3ba01d5a17745349b0165dd796eee8a2023-11-08T07:27:57ZengTrakya UniversityTrakya University Journal of Natural Sciences2528-96912019-04-01201192610.23902/trkjnat.50812069MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGENAbdulkadir Kocak0Müslüm Yıldız1GEBZE TECHNICAL UNIVERSITY, FACULTY OF BASIC SCIENCESGEBZE TECHNICAL UNIVERSITY, FACULTY OF BASIC SCIENCESNoroviruses are the main cause for acute gastroenteritis disease. They infect the host cell via interaction with HGBA receptors on the cell surface. Virus makes complex with cell surface receptors through its capsid protein VP1 to enter the cell. Although the protein has been successfully crystallized in the presence of some common glycans, the dynamic change in the protein structure when interacting with sugar moieties has yet to be fully elucidated. This is critically important since it leads to understanding the protein’s recognition mechanism of HBGAs and develop therapeutic strategies against the gastroenteritis disease. Here, we computationally assessed the dynamic features of wild type VP1 envelope protein to get insights into the interactions that can be important for virus infectivity. We have found that the binding of sugar moiety does not cause noticeable dynamic changes in the binding region. However, interestingly, a drastic change occurs in a distant loop lying at the residue numbers of 395-400, which might be indication of an allosteric effect.https://dergipark.org.tr/en/download/article-file/637369norovirustherapeutic antibodyhbga blockagemolecular dynamics |
| spellingShingle | Abdulkadir Kocak Müslüm Yıldız MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN Trakya University Journal of Natural Sciences norovirus therapeutic antibody hbga blockage molecular dynamics |
| title | MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN |
| title_full | MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN |
| title_fullStr | MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN |
| title_full_unstemmed | MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN |
| title_short | MOLECULAR DYNAMICS STUDIES OF THE NOROVIRUS-HOST CELL INTERACTION MEDIATED BY H-TYPE 1 ANTIGEN |
| title_sort | molecular dynamics studies of the norovirus host cell interaction mediated by h type 1 antigen |
| topic | norovirus therapeutic antibody hbga blockage molecular dynamics |
| url | https://dergipark.org.tr/en/download/article-file/637369 |
| work_keys_str_mv | AT abdulkadirkocak moleculardynamicsstudiesofthenorovirushostcellinteractionmediatedbyhtype1antigen AT muslumyıldız moleculardynamicsstudiesofthenorovirushostcellinteractionmediatedbyhtype1antigen |