Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study
IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed ca...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1029962/full |
| _version_ | 1811185168101146624 |
|---|---|
| author | Chun-Yen Huang Jia-In Lee Chia-Wen Chang Yao-Hua Liu Shu-Pin Huang Shu-Pin Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng |
| author_facet | Chun-Yen Huang Jia-In Lee Chia-Wen Chang Yao-Hua Liu Shu-Pin Huang Shu-Pin Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng |
| author_sort | Chun-Yen Huang |
| collection | DOAJ |
| description | IntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline.Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments. |
| first_indexed | 2024-04-11T13:25:54Z |
| format | Article |
| id | doaj.art-a3bad0ffb309443bbdfe2ecd2b0f9b2a |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T13:25:54Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-a3bad0ffb309443bbdfe2ecd2b0f9b2a2022-12-22T04:22:05ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-12-011010.3389/fpubh.2022.10299621029962Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal studyChun-Yen Huang0Jia-In Lee1Chia-Wen Chang2Yao-Hua Liu3Shu-Pin Huang4Shu-Pin Huang5Szu-Chia Chen6Szu-Chia Chen7Szu-Chia Chen8Szu-Chia Chen9Jiun-Hung Geng10Jiun-Hung Geng11Jiun-Hung Geng12Jiun-Hung Geng13Department of Emergency Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Emergency Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Emergency Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, TaiwanIntroductionWe aim to explore the association between chronic kidney disease (CKD) and cataracts.MethodsA total of 121,380 participants with adequate information collected from 29 community-based recruitment centers since 2008 were analyzed. The association between CKD and self-reported diagnosed cataracts was examined in a cross-sectional cohort and was validated in a longitudinal cohort of 25,263 participants without cataracts at baseline.Results and discussionOf all participants, cataracts occurred in 503/1,947 (26%) and 10,464/119,433 (9%) subjects in the CKD and non-CKD groups, respectively. Multivariate logistic regression showed that CKD was significantly associated with a higher prevalence of self-reported diagnosed cataracts. In the validation cohort, a higher incidence of cataracts was also noted in the CKD group (65/317, 21%) compared to the non-CKD group (1,964/24,252, 8%) during a mean 47-month follow-up. After adjusting for confounders, subjects with CKD had a 1.498-fold higher risk of incident cataracts than those without CKD (95% confidence interval = 1.114 to 2.013, p value = 0.007). We found that CKD was associated with a higher prevalence of cataracts as well as incident cataracts, which suggests CKD patients and their primary physicians should be aware of this disease and can provide a clue for further exploration of the possible mechanisms and treatments.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1029962/fullchronic kidney diseasecataractrisk factorsepidemiologylongitudinal cohortcross-sectional cohort |
| spellingShingle | Chun-Yen Huang Jia-In Lee Chia-Wen Chang Yao-Hua Liu Shu-Pin Huang Shu-Pin Huang Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Szu-Chia Chen Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng Jiun-Hung Geng Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study Frontiers in Public Health chronic kidney disease cataract risk factors epidemiology longitudinal cohort cross-sectional cohort |
| title | Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study |
| title_full | Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study |
| title_fullStr | Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study |
| title_full_unstemmed | Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study |
| title_short | Chronic kidney disease and its association with cataracts–A cross-sectional and longitudinal study |
| title_sort | chronic kidney disease and its association with cataracts a cross sectional and longitudinal study |
| topic | chronic kidney disease cataract risk factors epidemiology longitudinal cohort cross-sectional cohort |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1029962/full |
| work_keys_str_mv | AT chunyenhuang chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT jiainlee chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT chiawenchang chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT yaohualiu chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT shupinhuang chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT shupinhuang chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT szuchiachen chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT szuchiachen chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT szuchiachen chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT szuchiachen chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT jiunhunggeng chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT jiunhunggeng chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT jiunhunggeng chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy AT jiunhunggeng chronickidneydiseaseanditsassociationwithcataractsacrosssectionalandlongitudinalstudy |