The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study
Antimicrobial resistance is one of the major factors determining the efficacy of <i>Helicobacter pylori</i> eradication therapy. This study aimed to estimate the recent prevalence of multidrug resistance of <i>H. pylori</i> and its impact on eradication in Korea. A total of 1...
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MDPI AG
2020-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/10/646 |
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| author | Jae Yong Park Tae-Seop Shin Ji Hyun Kim Hong Jip Yoon Beom Jin Kim Jae Gyu Kim |
| author_facet | Jae Yong Park Tae-Seop Shin Ji Hyun Kim Hong Jip Yoon Beom Jin Kim Jae Gyu Kim |
| author_sort | Jae Yong Park |
| collection | DOAJ |
| description | Antimicrobial resistance is one of the major factors determining the efficacy of <i>Helicobacter pylori</i> eradication therapy. This study aimed to estimate the recent prevalence of multidrug resistance of <i>H. pylori</i> and its impact on eradication in Korea. A total of 174 patients were prospectively enrolled at Chung-Ang University Hospital from 2017 to 2019. <i>H. pylori</i> strains were isolated from the gastric body and antrum. The minimum inhibitory concentrations of antibiotics were determined by the serial twofold agar dilution method. Eradication results were reviewed and analyzed in connection with antibiotic resistance. The prevalence of <i>H. pylori</i> infection was 51.7% (90/174). The culture success rate was 77.8% (70/90). The resistance rates for clarithromycin, metronidazole, amoxicillin, tetracycline, levofloxacin, and moxifloxacin were 28.6% (20/70), 27.1% (19/70), 20.0% (14/70), 18.6% (13/70), 42.9% (30/70), and 42.9% (30/70), respectively. The multidrug resistance (resistance to two or more classes of antimicrobials) rate was 42.9% (30/70). Dual resistance to clarithromycin and metronidazole was confirmed in 8.6% (6/70). Eradication with a first-line treatment was successful in 75% (36/48), and those who received second-line treatment all achieved successful eradication. The rate of multidrug resistance is increasing, and standard triple therapy (STT) is no longer an acceptable first-line option for <i>H. pylori</i> eradication in Korea. |
| first_indexed | 2024-03-10T16:00:59Z |
| format | Article |
| id | doaj.art-a3bbf33e30d94ed6b953b475dc83d145 |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T16:00:59Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a3bbf33e30d94ed6b953b475dc83d1452023-11-20T15:19:42ZengMDPI AGAntibiotics2079-63822020-09-0191064610.3390/antibiotics9100646The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center StudyJae Yong Park0Tae-Seop Shin1Ji Hyun Kim2Hong Jip Yoon3Beom Jin Kim4Jae Gyu Kim5Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, KoreaMD Healthcare Inc., Seoul 03923, KoreaResearch Institute, Chung-Ang University, Seoul 06974, KoreaDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, KoreaDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, KoreaDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, KoreaAntimicrobial resistance is one of the major factors determining the efficacy of <i>Helicobacter pylori</i> eradication therapy. This study aimed to estimate the recent prevalence of multidrug resistance of <i>H. pylori</i> and its impact on eradication in Korea. A total of 174 patients were prospectively enrolled at Chung-Ang University Hospital from 2017 to 2019. <i>H. pylori</i> strains were isolated from the gastric body and antrum. The minimum inhibitory concentrations of antibiotics were determined by the serial twofold agar dilution method. Eradication results were reviewed and analyzed in connection with antibiotic resistance. The prevalence of <i>H. pylori</i> infection was 51.7% (90/174). The culture success rate was 77.8% (70/90). The resistance rates for clarithromycin, metronidazole, amoxicillin, tetracycline, levofloxacin, and moxifloxacin were 28.6% (20/70), 27.1% (19/70), 20.0% (14/70), 18.6% (13/70), 42.9% (30/70), and 42.9% (30/70), respectively. The multidrug resistance (resistance to two or more classes of antimicrobials) rate was 42.9% (30/70). Dual resistance to clarithromycin and metronidazole was confirmed in 8.6% (6/70). Eradication with a first-line treatment was successful in 75% (36/48), and those who received second-line treatment all achieved successful eradication. The rate of multidrug resistance is increasing, and standard triple therapy (STT) is no longer an acceptable first-line option for <i>H. pylori</i> eradication in Korea.https://www.mdpi.com/2079-6382/9/10/646<i>Helicobacter pylori</i>antibiotic resistanceeradicationKorea |
| spellingShingle | Jae Yong Park Tae-Seop Shin Ji Hyun Kim Hong Jip Yoon Beom Jin Kim Jae Gyu Kim The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study Antibiotics <i>Helicobacter pylori</i> antibiotic resistance eradication Korea |
| title | The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study |
| title_full | The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study |
| title_fullStr | The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study |
| title_full_unstemmed | The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study |
| title_short | The Prevalence of Multidrug Resistance of <i>Helicobacter pylori</i> and Its Impact on Eradication in Korea from 2017 to 2019: A Single-Center Study |
| title_sort | prevalence of multidrug resistance of i helicobacter pylori i and its impact on eradication in korea from 2017 to 2019 a single center study |
| topic | <i>Helicobacter pylori</i> antibiotic resistance eradication Korea |
| url | https://www.mdpi.com/2079-6382/9/10/646 |
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