The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington’s disease brain

Abstract Background The mechanisms underlying neurodegeneration in the striatum of Huntingon’s Disease (HD) brain are currently unknown. While the striatum is massively degenerated in symptomatic individuals, which makes cellular characterization difficult, it is largely intact in asymptomatic HD ge...

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Bibliographic Details
Main Authors: Filisia Agus, Diego Crespo, Richard H. Myers, Adam Labadorf
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Medical Genomics
Subjects:
Huntington’s disease
Neurodegeneration
Bioinformatics
High throughput mRNA sequencing
Differential expression
Machine learning
Online Access:http://link.springer.com/article/10.1186/s12920-019-0581-9

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