The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults
Abstract Background Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of compensation to amyloid; however, this is...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-019-0573-1 |
| _version_ | 1819056672152223744 |
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| author | Chemin Lin Maria Ly Helmet T. Karim Wenjing Wei Beth E. Snitz William E. Klunk Howard J. Aizenstein |
| author_facet | Chemin Lin Maria Ly Helmet T. Karim Wenjing Wei Beth E. Snitz William E. Klunk Howard J. Aizenstein |
| author_sort | Chemin Lin |
| collection | DOAJ |
| description | Abstract Background Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of compensation to amyloid; however, this is not well understood. Methods We recruited 64 cognitively normal older adults who underwent neuropsychological testing and biannual magnetic resonance imaging (MRI), amyloid imaging with Pittsburgh compound B (PiB)-PET, and glucose metabolism (FDG)-PET imaging for up to 6 years. Resting-state MRI was used to estimate connectivity of seven canonical neural networks using template-based rotation. Using voxel-wise paired t-tests, we identified neural networks that displayed significant changes in connectivity across time. We investigated associations among amyloid and longitudinal changes in connectivity and cognitive function by domains. Results Left middle frontal gyrus connectivity within the memory encoding network increased over time, but the rate of change was lower with greater amyloid. This was no longer significant in an analysis where we limited the sample to only those with two time points. We found limited decline in cognitive domains overall. Greater functional connectivity was associated with better attention/processing speed and executive function (independent of time) in those with lower amyloid but was associated with worse function with greater amyloid. Conclusions Increased functional connectivity serves to preserve cognitive function in normal aging and may fail in the presence of pathology consistent with compensatory models. |
| first_indexed | 2024-12-21T13:27:08Z |
| format | Article |
| id | doaj.art-a3be8f15641945a58a1955808916d54c |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-21T13:27:08Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-a3be8f15641945a58a1955808916d54c2022-12-21T19:02:25ZengBMCAlzheimer’s Research & Therapy1758-91932020-01-0112111010.1186/s13195-019-0573-1The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adultsChemin Lin0Maria Ly1Helmet T. Karim2Wenjing Wei3Beth E. Snitz4William E. Klunk5Howard J. Aizenstein6Department of Psychiatry, Keelung Chang Chung Memorial HospitalDepartment of Psychiatry, University of PittsburghDepartment of Psychiatry, University of PittsburghThe Third Xiangya Hospital of Central South UniversityDepartment of Neurology, University of PittsburghDepartment of Psychiatry, University of PittsburghDepartment of Psychiatry, University of PittsburghAbstract Background Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of compensation to amyloid; however, this is not well understood. Methods We recruited 64 cognitively normal older adults who underwent neuropsychological testing and biannual magnetic resonance imaging (MRI), amyloid imaging with Pittsburgh compound B (PiB)-PET, and glucose metabolism (FDG)-PET imaging for up to 6 years. Resting-state MRI was used to estimate connectivity of seven canonical neural networks using template-based rotation. Using voxel-wise paired t-tests, we identified neural networks that displayed significant changes in connectivity across time. We investigated associations among amyloid and longitudinal changes in connectivity and cognitive function by domains. Results Left middle frontal gyrus connectivity within the memory encoding network increased over time, but the rate of change was lower with greater amyloid. This was no longer significant in an analysis where we limited the sample to only those with two time points. We found limited decline in cognitive domains overall. Greater functional connectivity was associated with better attention/processing speed and executive function (independent of time) in those with lower amyloid but was associated with worse function with greater amyloid. Conclusions Increased functional connectivity serves to preserve cognitive function in normal aging and may fail in the presence of pathology consistent with compensatory models.https://doi.org/10.1186/s13195-019-0573-1Preclinical Alzheimer’s diseaseResting-state fMRILongitudinalCompensationHomeostatic regulationAmyloid |
| spellingShingle | Chemin Lin Maria Ly Helmet T. Karim Wenjing Wei Beth E. Snitz William E. Klunk Howard J. Aizenstein The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults Alzheimer’s Research & Therapy Preclinical Alzheimer’s disease Resting-state fMRI Longitudinal Compensation Homeostatic regulation Amyloid |
| title | The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults |
| title_full | The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults |
| title_fullStr | The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults |
| title_full_unstemmed | The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults |
| title_short | The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults |
| title_sort | effect of amyloid deposition on longitudinal resting state functional connectivity in cognitively normal older adults |
| topic | Preclinical Alzheimer’s disease Resting-state fMRI Longitudinal Compensation Homeostatic regulation Amyloid |
| url | https://doi.org/10.1186/s13195-019-0573-1 |
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