Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance
The incessant developments in the pharmaceutical and biomedical fields, particularly, customised solutions for specific diseases with targeted therapeutic treatments, require the design of multicomponent materials with multifunctional capabilities. Biodegradable polymers offer a variety of tailored...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/8/1673 |
| _version_ | 1797408387798925312 |
|---|---|
| author | Carmen Moya-Lopez Joaquín González-Fuentes Iván Bravo David Chapron Patrice Bourson Carlos Alonso-Moreno Daniel Hermida-Merino |
| author_facet | Carmen Moya-Lopez Joaquín González-Fuentes Iván Bravo David Chapron Patrice Bourson Carlos Alonso-Moreno Daniel Hermida-Merino |
| author_sort | Carmen Moya-Lopez |
| collection | DOAJ |
| description | The incessant developments in the pharmaceutical and biomedical fields, particularly, customised solutions for specific diseases with targeted therapeutic treatments, require the design of multicomponent materials with multifunctional capabilities. Biodegradable polymers offer a variety of tailored physicochemical properties minimising health adverse side effects at a low price and weight, which are ideal to design matrices for hybrid materials. PLAs emerge as an ideal candidate to develop novel materials as are endowed withcombined ambivalent performance parameters. The state-of-the-art of use of PLA-based materials aimed at pharmaceutical and biomedical applications is reviewed, with an emphasis on the correlation between the synthesis and the processing conditions that define the nanostructure generated, with the final performance studies typically conducted with either therapeutic agents by in vitro and/or in vivo experiments or biomedical devices. |
| first_indexed | 2024-03-09T03:57:44Z |
| format | Article |
| id | doaj.art-a3c029d044344f1b92fe0816459dd2c5 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T03:57:44Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a3c029d044344f1b92fe0816459dd2c52023-12-03T14:17:39ZengMDPI AGPharmaceutics1999-49232022-08-01148167310.3390/pharmaceutics14081673Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application PerformanceCarmen Moya-Lopez0Joaquín González-Fuentes1Iván Bravo2David Chapron3Patrice Bourson4Carlos Alonso-Moreno5Daniel Hermida-Merino6Laboratoire Matériaux Optiques Photonique et Systèmes (LMOPS), CentraleSupélec, Université de Lorraine, 57000 Metz, FranceCentro Regional de Investigaciones Biomédicas (CRIB), 02008 Albacete, SpainFacultad de Farmacia de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, SpainLaboratoire Matériaux Optiques Photonique et Systèmes (LMOPS), CentraleSupélec, Université de Lorraine, 57000 Metz, FranceLaboratoire Matériaux Optiques Photonique et Systèmes (LMOPS), CentraleSupélec, Université de Lorraine, 57000 Metz, FranceFacultad de Farmacia de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, SpainDUBBLE@ESRF BP CS40220, 38043 Grenoble, FranceThe incessant developments in the pharmaceutical and biomedical fields, particularly, customised solutions for specific diseases with targeted therapeutic treatments, require the design of multicomponent materials with multifunctional capabilities. Biodegradable polymers offer a variety of tailored physicochemical properties minimising health adverse side effects at a low price and weight, which are ideal to design matrices for hybrid materials. PLAs emerge as an ideal candidate to develop novel materials as are endowed withcombined ambivalent performance parameters. The state-of-the-art of use of PLA-based materials aimed at pharmaceutical and biomedical applications is reviewed, with an emphasis on the correlation between the synthesis and the processing conditions that define the nanostructure generated, with the final performance studies typically conducted with either therapeutic agents by in vitro and/or in vivo experiments or biomedical devices.https://www.mdpi.com/1999-4923/14/8/1673polylactidestereocomplexbiomedicineprocessing conditionstailored pharmaceutical treatmentspersonalised medicine |
| spellingShingle | Carmen Moya-Lopez Joaquín González-Fuentes Iván Bravo David Chapron Patrice Bourson Carlos Alonso-Moreno Daniel Hermida-Merino Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance Pharmaceutics polylactide stereocomplex biomedicine processing conditions tailored pharmaceutical treatments personalised medicine |
| title | Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance |
| title_full | Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance |
| title_fullStr | Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance |
| title_full_unstemmed | Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance |
| title_short | Polylactide Perspectives in Biomedicine: From Novel Synthesis to the Application Performance |
| title_sort | polylactide perspectives in biomedicine from novel synthesis to the application performance |
| topic | polylactide stereocomplex biomedicine processing conditions tailored pharmaceutical treatments personalised medicine |
| url | https://www.mdpi.com/1999-4923/14/8/1673 |
| work_keys_str_mv | AT carmenmoyalopez polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT joaquingonzalezfuentes polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT ivanbravo polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT davidchapron polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT patricebourson polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT carlosalonsomoreno polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance AT danielhermidamerino polylactideperspectivesinbiomedicinefromnovelsynthesistotheapplicationperformance |