Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study
Abstract Background Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibioti...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-3889-3 |
| _version_ | 1818338669440794624 |
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| author | László Róbert Kolozsvári József Kónya John Paget Francois G. Schellevis János Sándor Gergő József Szőllősi Szilvia Harsányi Zoltán Jancsó Imre Rurik |
| author_facet | László Róbert Kolozsvári József Kónya John Paget Francois G. Schellevis János Sándor Gergő József Szőllősi Szilvia Harsányi Zoltán Jancsó Imre Rurik |
| author_sort | László Róbert Kolozsvári |
| collection | DOAJ |
| description | Abstract Background Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. Methods The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman’s rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). Results According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021). Conclusions The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance. |
| first_indexed | 2024-12-13T15:14:47Z |
| format | Article |
| id | doaj.art-a3c05cbe5ec24953a642e40da3ad41e9 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T15:14:47Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-a3c05cbe5ec24953a642e40da3ad41e92022-12-21T23:40:45ZengBMCBMC Infectious Diseases1471-23342019-03-011911810.1186/s12879-019-3889-3Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES studyLászló Róbert Kolozsvári0József Kónya1John Paget2Francois G. Schellevis3János Sándor4Gergő József Szőllősi5Szilvia Harsányi6Zoltán Jancsó7Imre Rurik8Department of Family and Occupational Medicine, Faculty of Public Health, University of DebrecenDepartment of Medical Microbiology, Faculty of Medicine, University of DebrecenNIVEL, The Netherlands Institute for Health Services ResearchNIVEL, The Netherlands Institute for Health Services ResearchDepartment of Preventive Medicine, Faculty of Public Health, University of DebrecenDepartment of Preventive Medicine, Faculty of Public Health, University of DebrecenDepartment of Health Systems Management, Faculty of Public Health, University of DebrecenDepartment of Family and Occupational Medicine, Faculty of Public Health, University of DebrecenDepartment of Family and Occupational Medicine, Faculty of Public Health, University of DebrecenAbstract Background Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. Methods The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman’s rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). Results According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021). Conclusions The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance.http://link.springer.com/article/10.1186/s12879-019-3889-3Antimicrobial resistanceAntibacterial resistanceCommensalHealthy populationPatient-related factorsStaphylococcus aureus |
| spellingShingle | László Róbert Kolozsvári József Kónya John Paget Francois G. Schellevis János Sándor Gergő József Szőllősi Szilvia Harsányi Zoltán Jancsó Imre Rurik Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study BMC Infectious Diseases Antimicrobial resistance Antibacterial resistance Commensal Healthy population Patient-related factors Staphylococcus aureus |
| title | Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study |
| title_full | Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study |
| title_fullStr | Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study |
| title_full_unstemmed | Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study |
| title_short | Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study |
| title_sort | patient related factors antibiotic prescribing and antimicrobial resistance of the commensal staphylococcus aureus and streptococcus pneumoniae in a healthy population hungarian results of the apres study |
| topic | Antimicrobial resistance Antibacterial resistance Commensal Healthy population Patient-related factors Staphylococcus aureus |
| url | http://link.springer.com/article/10.1186/s12879-019-3889-3 |
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