Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor
This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/10/8/2848 |
| _version_ | 1797570127493857280 |
|---|---|
| author | Lijuan Huang Ziru Jia Hongying Liu Xitian Pi Jiawen Zhou |
| author_facet | Lijuan Huang Ziru Jia Hongying Liu Xitian Pi Jiawen Zhou |
| author_sort | Lijuan Huang |
| collection | DOAJ |
| description | This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes. |
| first_indexed | 2024-03-10T20:21:29Z |
| format | Article |
| id | doaj.art-a3c0e1151c9e42b491dd7ef2d23db587 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T20:21:29Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-a3c0e1151c9e42b491dd7ef2d23db5872023-11-19T22:11:35ZengMDPI AGApplied Sciences2076-34172020-04-01108284810.3390/app10082848Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose SensorLijuan Huang0Ziru Jia1Hongying Liu2Xitian Pi3Jiawen Zhou4Key Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, ChinaKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, ChinaKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, ChinaKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, ChinaKey Laboratory of Biotechnology Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, ChinaThis study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.https://www.mdpi.com/2076-3417/10/8/2848glucose sensorhierarchically porous structureoxygen regenerationpolyurethanepolyethylene glycol |
| spellingShingle | Lijuan Huang Ziru Jia Hongying Liu Xitian Pi Jiawen Zhou Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor Applied Sciences glucose sensor hierarchically porous structure oxygen regeneration polyurethane polyethylene glycol |
| title | Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor |
| title_full | Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor |
| title_fullStr | Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor |
| title_full_unstemmed | Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor |
| title_short | Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor |
| title_sort | design of a sandwich hierarchically porous membrane with oxygen supplement function for implantable glucose sensor |
| topic | glucose sensor hierarchically porous structure oxygen regeneration polyurethane polyethylene glycol |
| url | https://www.mdpi.com/2076-3417/10/8/2848 |
| work_keys_str_mv | AT lijuanhuang designofasandwichhierarchicallyporousmembranewithoxygensupplementfunctionforimplantableglucosesensor AT zirujia designofasandwichhierarchicallyporousmembranewithoxygensupplementfunctionforimplantableglucosesensor AT hongyingliu designofasandwichhierarchicallyporousmembranewithoxygensupplementfunctionforimplantableglucosesensor AT xitianpi designofasandwichhierarchicallyporousmembranewithoxygensupplementfunctionforimplantableglucosesensor AT jiawenzhou designofasandwichhierarchicallyporousmembranewithoxygensupplementfunctionforimplantableglucosesensor |