Bisphenol S negatively affects the meotic maturation of pig oocytes
Abstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00570-5 |
| _version_ | 1818431081934749696 |
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| author | Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr |
| author_facet | Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr |
| author_sort | Tereza Žalmanová |
| collection | DOAJ |
| description | Abstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced. |
| first_indexed | 2024-12-14T15:43:38Z |
| format | Article |
| id | doaj.art-a3c199e4c7a94e34b5435a12c0cad3ce |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:43:38Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a3c199e4c7a94e34b5435a12c0cad3ce2022-12-21T22:55:34ZengNature PortfolioScientific Reports2045-23222017-03-017111110.1038/s41598-017-00570-5Bisphenol S negatively affects the meotic maturation of pig oocytesTereza Žalmanová0Kristýna Hošková1Jan Nevoral2Kateřina Adámková3Tomáš Kott4Miloslav Šulc5Zora Kotíková6Šárka Prokešová7František Jílek8Milena Králíčková9Jaroslav Petr10Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesInstitute of Animal ScienceCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of ChemistryCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of ChemistryCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesCzech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary SciencesCharles University in Prague, Faculty of Medicine in Pilsen, Biomedical Center and Department of Histology and EmbryologyInstitute of Animal ScienceAbstract Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.https://doi.org/10.1038/s41598-017-00570-5 |
| spellingShingle | Tereza Žalmanová Kristýna Hošková Jan Nevoral Kateřina Adámková Tomáš Kott Miloslav Šulc Zora Kotíková Šárka Prokešová František Jílek Milena Králíčková Jaroslav Petr Bisphenol S negatively affects the meotic maturation of pig oocytes Scientific Reports |
| title | Bisphenol S negatively affects the meotic maturation of pig oocytes |
| title_full | Bisphenol S negatively affects the meotic maturation of pig oocytes |
| title_fullStr | Bisphenol S negatively affects the meotic maturation of pig oocytes |
| title_full_unstemmed | Bisphenol S negatively affects the meotic maturation of pig oocytes |
| title_short | Bisphenol S negatively affects the meotic maturation of pig oocytes |
| title_sort | bisphenol s negatively affects the meotic maturation of pig oocytes |
| url | https://doi.org/10.1038/s41598-017-00570-5 |
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