Mitochondrial stress response and myogenic differentiation
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of m...
| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Frontiers Media S.A.
2024-04-01
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| Edice: | Frontiers in Cell and Developmental Biology |
| Témata: | |
| On-line přístup: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1381417/full |
| _version_ | 1827287467949031424 |
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| author | Fu Lin Liankun Sun Yu Zhang Weinan Gao Zihan Chen Zihan Chen Yanan Liu Kai Tian Kai Tian Xuyu Han Xuyu Han Ruize Liu Ruize Liu Yang Li Luyan Shen |
| author_facet | Fu Lin Liankun Sun Yu Zhang Weinan Gao Zihan Chen Zihan Chen Yanan Liu Kai Tian Kai Tian Xuyu Han Xuyu Han Ruize Liu Ruize Liu Yang Li Luyan Shen |
| author_sort | Fu Lin |
| collection | DOAJ |
| description | Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of mitochondria in number and function. Mitochondrial dysfunction can activate a number of transcriptional, translational and post-translational programmes and pathways to maintain cellular homeostasis under different types and degrees of stress, either through its own signaling or through constant signaling interactions with the nucleus and cytoplasm, a process known as the mitochondrial stress responses (MSRs). It is now believed that mitochondrial dysfunction is closely associated with a variety of muscle diseases caused by reduced levels of myogenic differentiation, suggesting the possibility that MSRs are involved in messaging during myogenic differentiation. Also, MSRs may be involved in myogenesis by promoting bioenergetic remodeling and assisting myoblast survival during myogenic differentiation. In this review, we will take MSRs as an entry point to explore its concrete regulatory mechanisms during myogenic differentiation, with a perspective to provide a theoretical basis for the treatment and repair of related muscle diseases. |
| first_indexed | 2024-04-24T10:59:58Z |
| format | Article |
| id | doaj.art-a3c30c005db14ee7bddc2783d5f95d4d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-24T10:59:58Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a3c30c005db14ee7bddc2783d5f95d4d2024-04-12T04:15:55ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-04-011210.3389/fcell.2024.13814171381417Mitochondrial stress response and myogenic differentiationFu Lin0Liankun Sun1Yu Zhang2Weinan Gao3Zihan Chen4Zihan Chen5Yanan Liu6Kai Tian7Kai Tian8Xuyu Han9Xuyu Han10Ruize Liu11Ruize Liu12Yang Li13Luyan Shen14Key Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaExperimental Teaching Center of Basic Medicine, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaClinical Medical College of Jilin University, The First Hospital of Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaChina Japan Union Hospital of Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaChina Japan Union Hospital of Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaChina Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Physiology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Pathobiology, Department of Pathophysiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, ChinaRegeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of mitochondria in number and function. Mitochondrial dysfunction can activate a number of transcriptional, translational and post-translational programmes and pathways to maintain cellular homeostasis under different types and degrees of stress, either through its own signaling or through constant signaling interactions with the nucleus and cytoplasm, a process known as the mitochondrial stress responses (MSRs). It is now believed that mitochondrial dysfunction is closely associated with a variety of muscle diseases caused by reduced levels of myogenic differentiation, suggesting the possibility that MSRs are involved in messaging during myogenic differentiation. Also, MSRs may be involved in myogenesis by promoting bioenergetic remodeling and assisting myoblast survival during myogenic differentiation. In this review, we will take MSRs as an entry point to explore its concrete regulatory mechanisms during myogenic differentiation, with a perspective to provide a theoretical basis for the treatment and repair of related muscle diseases.https://www.frontiersin.org/articles/10.3389/fcell.2024.1381417/fullmyogenic differentiationISRUPRmtmitochondrial biogenesismitochondrial fusion and fissionmitophagy |
| spellingShingle | Fu Lin Liankun Sun Yu Zhang Weinan Gao Zihan Chen Zihan Chen Yanan Liu Kai Tian Kai Tian Xuyu Han Xuyu Han Ruize Liu Ruize Liu Yang Li Luyan Shen Mitochondrial stress response and myogenic differentiation Frontiers in Cell and Developmental Biology myogenic differentiation ISR UPRmt mitochondrial biogenesis mitochondrial fusion and fission mitophagy |
| title | Mitochondrial stress response and myogenic differentiation |
| title_full | Mitochondrial stress response and myogenic differentiation |
| title_fullStr | Mitochondrial stress response and myogenic differentiation |
| title_full_unstemmed | Mitochondrial stress response and myogenic differentiation |
| title_short | Mitochondrial stress response and myogenic differentiation |
| title_sort | mitochondrial stress response and myogenic differentiation |
| topic | myogenic differentiation ISR UPRmt mitochondrial biogenesis mitochondrial fusion and fission mitophagy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1381417/full |
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