Anti-rods/rings: a human model of drug-induced autoantibody generation

In recent years, autoantibodies targeting subcellular structures described as the rods and rings pattern in HEp-2 ANA have been presented as a unique case of autoantibody generation. These rod and ring structures (RR) are at least partially composed of inosine monophosphate dehydrogenase type 2 (IMP...

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Bibliographic Details
Main Authors: S. John eCalise, Gerson D Keppeke, Luis E. Coelho Andrade, Edward K. L Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00041/full