Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration
Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective curative treatment for neurodegenerative diseases. Poly...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3523 |
| _version_ | 1797547779993632768 |
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| author | Morteza Sarparast Devon Dattmore Jamie Alan Kin Sing Stephen Lee |
| author_facet | Morteza Sarparast Devon Dattmore Jamie Alan Kin Sing Stephen Lee |
| author_sort | Morteza Sarparast |
| collection | DOAJ |
| description | Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective curative treatment for neurodegenerative diseases. Polyunsaturated fatty acids (PUFAs) have become an emerging dietary medical intervention for health maintenance and treatment of diseases, including neurodegenerative diseases. Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease; however, their mechanism(s) remains unclear. The endogenous levels of CYP metabolites are greatly affected by our diet, endogenous synthesis, and the downstream metabolism. While the activity of omega-3 (ω-3) CYP PUFA metabolites and omega-6 (ω-6) CYP PUFA metabolites largely overlap, the ω-3 CYP PUFA metabolites are more active in general. In this review, we will briefly summarize recent findings regarding the biosynthesis and metabolism of CYP PUFA metabolites. We will also discuss the potential mechanism(s) of CYP PUFA metabolites in neurodegeneration, which will ultimately improve our understanding of how PUFAs affect neurodegeneration and may identify potential drug targets for neurodegenerative diseases. |
| first_indexed | 2024-03-10T14:49:58Z |
| format | Article |
| id | doaj.art-a3c62e16001c41408b6c1c327b0708a8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:49:58Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a3c62e16001c41408b6c1c327b0708a82023-11-20T21:06:35ZengMDPI AGNutrients2072-66432020-11-011211352310.3390/nu12113523Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and NeurodegenerationMorteza Sarparast0Devon Dattmore1Jamie Alan2Kin Sing Stephen Lee3Department of Chemistry, Michigan State University, East Lansing, MI 48824, USADepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USADepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USADepartment of Chemistry, Michigan State University, East Lansing, MI 48824, USADue to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective curative treatment for neurodegenerative diseases. Polyunsaturated fatty acids (PUFAs) have become an emerging dietary medical intervention for health maintenance and treatment of diseases, including neurodegenerative diseases. Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease; however, their mechanism(s) remains unclear. The endogenous levels of CYP metabolites are greatly affected by our diet, endogenous synthesis, and the downstream metabolism. While the activity of omega-3 (ω-3) CYP PUFA metabolites and omega-6 (ω-6) CYP PUFA metabolites largely overlap, the ω-3 CYP PUFA metabolites are more active in general. In this review, we will briefly summarize recent findings regarding the biosynthesis and metabolism of CYP PUFA metabolites. We will also discuss the potential mechanism(s) of CYP PUFA metabolites in neurodegeneration, which will ultimately improve our understanding of how PUFAs affect neurodegeneration and may identify potential drug targets for neurodegenerative diseases.https://www.mdpi.com/2072-6643/12/11/3523polyunsaturated fatty acidcytochrome P450epoxy-polyunsaturated fatty acidneurodegenerationneurodegenerative diseasedietary intervention |
| spellingShingle | Morteza Sarparast Devon Dattmore Jamie Alan Kin Sing Stephen Lee Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration Nutrients polyunsaturated fatty acid cytochrome P450 epoxy-polyunsaturated fatty acid neurodegeneration neurodegenerative disease dietary intervention |
| title | Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration |
| title_full | Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration |
| title_fullStr | Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration |
| title_full_unstemmed | Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration |
| title_short | Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration |
| title_sort | cytochrome p450 metabolism of polyunsaturated fatty acids and neurodegeneration |
| topic | polyunsaturated fatty acid cytochrome P450 epoxy-polyunsaturated fatty acid neurodegeneration neurodegenerative disease dietary intervention |
| url | https://www.mdpi.com/2072-6643/12/11/3523 |
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