Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction
Abstract Background Proprotein convertase subtilisin/kexin type 9 (Pcsk9) correlated with incidence and prognosis of coronary heart disease. However, it is unclear whether Pcsk9 contributed to coronary artery lesion severity in patients with premature myocardial infarction (PMI). The present study i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-021-01478-w |
| _version_ | 1818600951378870272 |
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| author | Jing Gao Ya-Nan Yang Zhuang Cui Si-Yuan Feng Jing Ma Chang-Ping Li Yin Liu |
| author_facet | Jing Gao Ya-Nan Yang Zhuang Cui Si-Yuan Feng Jing Ma Chang-Ping Li Yin Liu |
| author_sort | Jing Gao |
| collection | DOAJ |
| description | Abstract Background Proprotein convertase subtilisin/kexin type 9 (Pcsk9) correlated with incidence and prognosis of coronary heart disease. However, it is unclear whether Pcsk9 contributed to coronary artery lesion severity in patients with premature myocardial infarction (PMI). The present study investigated associations between Pcsk9 and coronary artery lesion severity in PMI patients who underwent coronary angiography (CAG). Methods This prospective cohort study included young men (age ≤ 45 years, n = 332) with acute MI who underwent CAG between January 2017 and July 2019. Serum Pcsk9 levels and clinical characteristics were evaluated. SYNTAX scores (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) were calculated to quantify coronary artery lesions. Results Serum Pcsk9 levels were positively associated with SYNTAX scores (r = 0.173, P < 0.05). The diagnostic cutoff value of PSCK9 level was 122.9 ng/mL, yielding an area under the curve (AUC) of 0.63, sensitivity 81%, and specificity 40%. Serum Pcsk9, LDL-C, Apob, NT-proBnp, CK level, and diabetes history were independent predictors of high SYNTAX scores (P < 0.05). After stratifying by serum LDL-C level (cutoff = 2.6 mmol/L), medium-high Pcsk9 levels had increased risk of high SYNTAX scores in patients with high LDL-C (P < 0.05), and higher serum Pcsk9 levels had increased risk of major adverse cardiac events (MACE) after adjusting for confounding factors (P < 0.05). Conclusion Serum Pcsk9 levels correlates with severity of coronary artery lesion in PMI patients and may serve as a biomarker for severity of coronary artery stenosis in this patient population, which may contribute to risk stratification. |
| first_indexed | 2024-12-16T12:43:39Z |
| format | Article |
| id | doaj.art-a3c81f8b89e042a58fdabc9bd8f6aec7 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-16T12:43:39Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a3c81f8b89e042a58fdabc9bd8f6aec72022-12-21T22:31:21ZengBMCLipids in Health and Disease1476-511X2021-05-0120111010.1186/s12944-021-01478-wPcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarctionJing Gao0Ya-Nan Yang1Zhuang Cui2Si-Yuan Feng3Jing Ma4Chang-Ping Li5Yin Liu6Chest Hospital, Tianjin UniversityTianjin Medical UniversityTianjin Medical UniversityTianjin Medical UniversityCardiovascular Institute, Tianjin Chest HospitalTianjin Medical UniversityThoracic Clinical College, Tianjin Medical UniversityAbstract Background Proprotein convertase subtilisin/kexin type 9 (Pcsk9) correlated with incidence and prognosis of coronary heart disease. However, it is unclear whether Pcsk9 contributed to coronary artery lesion severity in patients with premature myocardial infarction (PMI). The present study investigated associations between Pcsk9 and coronary artery lesion severity in PMI patients who underwent coronary angiography (CAG). Methods This prospective cohort study included young men (age ≤ 45 years, n = 332) with acute MI who underwent CAG between January 2017 and July 2019. Serum Pcsk9 levels and clinical characteristics were evaluated. SYNTAX scores (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) were calculated to quantify coronary artery lesions. Results Serum Pcsk9 levels were positively associated with SYNTAX scores (r = 0.173, P < 0.05). The diagnostic cutoff value of PSCK9 level was 122.9 ng/mL, yielding an area under the curve (AUC) of 0.63, sensitivity 81%, and specificity 40%. Serum Pcsk9, LDL-C, Apob, NT-proBnp, CK level, and diabetes history were independent predictors of high SYNTAX scores (P < 0.05). After stratifying by serum LDL-C level (cutoff = 2.6 mmol/L), medium-high Pcsk9 levels had increased risk of high SYNTAX scores in patients with high LDL-C (P < 0.05), and higher serum Pcsk9 levels had increased risk of major adverse cardiac events (MACE) after adjusting for confounding factors (P < 0.05). Conclusion Serum Pcsk9 levels correlates with severity of coronary artery lesion in PMI patients and may serve as a biomarker for severity of coronary artery stenosis in this patient population, which may contribute to risk stratification.https://doi.org/10.1186/s12944-021-01478-wCoronary angiographyCoronary artery diseasePremature myocardial infarctionProprotein convertase subtilisin/kexin type 9 |
| spellingShingle | Jing Gao Ya-Nan Yang Zhuang Cui Si-Yuan Feng Jing Ma Chang-Ping Li Yin Liu Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction Lipids in Health and Disease Coronary angiography Coronary artery disease Premature myocardial infarction Proprotein convertase subtilisin/kexin type 9 |
| title | Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| title_full | Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| title_fullStr | Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| title_full_unstemmed | Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| title_short | Pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| title_sort | pcsk9 is associated with severity of coronary artery lesions in male patients with premature myocardial infarction |
| topic | Coronary angiography Coronary artery disease Premature myocardial infarction Proprotein convertase subtilisin/kexin type 9 |
| url | https://doi.org/10.1186/s12944-021-01478-w |
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