DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

IntroductionDamage specific DNA binding protein 2 (DDB2) is an UV-indiced DNA damage recognition factor and regulator of cancer development and progression. DDB2 has dual roles in several cancers, either as an oncogene or as a tumor suppressor gene, depending on cancer localization. Here, we investi...

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Bibliographic Details
Main Authors: Julie Dardare, Andréa Witz, Margaux Betz, Aurélie Francois, Morgane Meras, Laureline Lamy, Aurélien Lambert, Stéphanie Grandemange, Marie Husson, Marie Rouyer, Jessica Demange, Jean-Louis Merlin, Alexandre Harlé, Pauline Gilson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
damage specific DNA binding protein 2
pancreatic ductal adenocarcinoma
epithelial-to-mesenchymal transition
chemosensitivity
biomarker
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1052163/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1052163/full

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