HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses
SARS-CoV-2, a novel betacoronavirus strain, has caused a pandemic that has claimed the lives of nearly 6.7M people worldwide. Vaccines and medicines are being developed around the world to reduce the disease spread, fatality rates, and control the new variants. Understanding the protein-protein inte...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/2/492 |
| _version_ | 1797617802550444032 |
|---|---|
| author | Naveen Duhan Rakesh Kaundal |
| author_facet | Naveen Duhan Rakesh Kaundal |
| author_sort | Naveen Duhan |
| collection | DOAJ |
| description | SARS-CoV-2, a novel betacoronavirus strain, has caused a pandemic that has claimed the lives of nearly 6.7M people worldwide. Vaccines and medicines are being developed around the world to reduce the disease spread, fatality rates, and control the new variants. Understanding the protein-protein interaction mechanism of SARS-CoV-2 in humans, and their comparison with the previous SARS-CoV and MERS strains, is crucial for these efforts. These interactions might be used to assess vaccination effectiveness, diagnose exposure, and produce effective biotherapeutics. Here, we present the HuCoPIA database, which contains approximately 100,000 protein-protein interactions between humans and three strains (SARS-CoV-2, SARS-CoV, and MERS) of betacoronavirus. The interactions in the database are divided into common interactions between all three strains and those unique to each strain. It also contains relevant functional annotation information of human proteins. The HuCoPIA database contains SARS-CoV-2 (41,173), SARS-CoV (31,997), and MERS (26,862) interactions, with functional annotation of human proteins like subcellular localization, tissue-expression, KEGG pathways, and Gene ontology information. We believe HuCoPIA will serve as an invaluable resource to diverse experimental biologists, and will help to advance the research in better understanding the mechanism of betacoronaviruses. |
| first_indexed | 2024-03-11T08:00:57Z |
| format | Article |
| id | doaj.art-a3cac5b64bd447f9b82dca1e8d806002 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:00:57Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a3cac5b64bd447f9b82dca1e8d8060022023-11-16T23:49:45ZengMDPI AGViruses1999-49152023-02-0115249210.3390/v15020492HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family VirusesNaveen Duhan0Rakesh Kaundal1Department of Plants, Soils, and Climate/Center for Integrated BioSystems, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USADepartment of Plants, Soils, and Climate/Center for Integrated BioSystems, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USASARS-CoV-2, a novel betacoronavirus strain, has caused a pandemic that has claimed the lives of nearly 6.7M people worldwide. Vaccines and medicines are being developed around the world to reduce the disease spread, fatality rates, and control the new variants. Understanding the protein-protein interaction mechanism of SARS-CoV-2 in humans, and their comparison with the previous SARS-CoV and MERS strains, is crucial for these efforts. These interactions might be used to assess vaccination effectiveness, diagnose exposure, and produce effective biotherapeutics. Here, we present the HuCoPIA database, which contains approximately 100,000 protein-protein interactions between humans and three strains (SARS-CoV-2, SARS-CoV, and MERS) of betacoronavirus. The interactions in the database are divided into common interactions between all three strains and those unique to each strain. It also contains relevant functional annotation information of human proteins. The HuCoPIA database contains SARS-CoV-2 (41,173), SARS-CoV (31,997), and MERS (26,862) interactions, with functional annotation of human proteins like subcellular localization, tissue-expression, KEGG pathways, and Gene ontology information. We believe HuCoPIA will serve as an invaluable resource to diverse experimental biologists, and will help to advance the research in better understanding the mechanism of betacoronaviruses.https://www.mdpi.com/1999-4915/15/2/492humanSARS-CoV-2SARS-CoVMERSprotein-protein interactions |
| spellingShingle | Naveen Duhan Rakesh Kaundal HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses Viruses human SARS-CoV-2 SARS-CoV MERS protein-protein interactions |
| title | HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses |
| title_full | HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses |
| title_fullStr | HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses |
| title_full_unstemmed | HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses |
| title_short | HuCoPIA: An Atlas of Human vs. SARS-CoV-2 Interactome and the Comparative Analysis with Other <i>Coronaviridae</i> Family Viruses |
| title_sort | hucopia an atlas of human vs sars cov 2 interactome and the comparative analysis with other i coronaviridae i family viruses |
| topic | human SARS-CoV-2 SARS-CoV MERS protein-protein interactions |
| url | https://www.mdpi.com/1999-4915/15/2/492 |
| work_keys_str_mv | AT naveenduhan hucopiaanatlasofhumanvssarscov2interactomeandthecomparativeanalysiswithothericoronaviridaeifamilyviruses AT rakeshkaundal hucopiaanatlasofhumanvssarscov2interactomeandthecomparativeanalysiswithothericoronaviridaeifamilyviruses |