Mouse allergen, lung function, and atopy in Puerto Rican children.
To examine the relation between mouse allergen exposure and asthma in Puerto Rican children.Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puert...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3398035?pdf=render |
| _version_ | 1828445472549765120 |
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| author | Erick Forno Michelle M Cloutier Soma Datta Kathryn Paul Jody Sylvia Deanna Calvert Sherell Thornton-Thompson Dorothy B Wakefield John Brehm Robert G Hamilton María Alvarez Angel Colón-Semidey Edna Acosta-Pérez Glorisa Canino Juan C Celedón |
| author_facet | Erick Forno Michelle M Cloutier Soma Datta Kathryn Paul Jody Sylvia Deanna Calvert Sherell Thornton-Thompson Dorothy B Wakefield John Brehm Robert G Hamilton María Alvarez Angel Colón-Semidey Edna Acosta-Pérez Glorisa Canino Juan C Celedón |
| author_sort | Erick Forno |
| collection | DOAJ |
| description | To examine the relation between mouse allergen exposure and asthma in Puerto Rican children.Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV(1) and FEV(1)/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures.Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV(1) in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6-132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = -0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5-0.9, P<0.01). In a multivariate analysis including all children at both study sites, each log-increment in mouse allergen was positively associated with FEV(1) (+28.3 ml, 95% CI = 1.4-55.2 ml, P = 0.04) and inversely associated with STR to ≥1 allergen (OR for each log-unit increment in Mus m 1 = 0.8, 95% CI = 0.6-0.9, P<0.01).Mouse allergen is associated with a higher FEV(1) and lower odds of STR to ≥1 allergen in Puerto Rican children. This may be explained by the allergen itself or correlated microbial exposures. |
| first_indexed | 2024-12-10T21:58:35Z |
| format | Article |
| id | doaj.art-a3ccb0ec479241baa008e502cdd519c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T21:58:35Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a3ccb0ec479241baa008e502cdd519c52022-12-22T01:31:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4038310.1371/journal.pone.0040383Mouse allergen, lung function, and atopy in Puerto Rican children.Erick FornoMichelle M CloutierSoma DattaKathryn PaulJody SylviaDeanna CalvertSherell Thornton-ThompsonDorothy B WakefieldJohn BrehmRobert G HamiltonMaría AlvarezAngel Colón-SemideyEdna Acosta-PérezGlorisa CaninoJuan C CeledónTo examine the relation between mouse allergen exposure and asthma in Puerto Rican children.Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV(1) and FEV(1)/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures.Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV(1) in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6-132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = -0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5-0.9, P<0.01). In a multivariate analysis including all children at both study sites, each log-increment in mouse allergen was positively associated with FEV(1) (+28.3 ml, 95% CI = 1.4-55.2 ml, P = 0.04) and inversely associated with STR to ≥1 allergen (OR for each log-unit increment in Mus m 1 = 0.8, 95% CI = 0.6-0.9, P<0.01).Mouse allergen is associated with a higher FEV(1) and lower odds of STR to ≥1 allergen in Puerto Rican children. This may be explained by the allergen itself or correlated microbial exposures.http://europepmc.org/articles/PMC3398035?pdf=render |
| spellingShingle | Erick Forno Michelle M Cloutier Soma Datta Kathryn Paul Jody Sylvia Deanna Calvert Sherell Thornton-Thompson Dorothy B Wakefield John Brehm Robert G Hamilton María Alvarez Angel Colón-Semidey Edna Acosta-Pérez Glorisa Canino Juan C Celedón Mouse allergen, lung function, and atopy in Puerto Rican children. PLoS ONE |
| title | Mouse allergen, lung function, and atopy in Puerto Rican children. |
| title_full | Mouse allergen, lung function, and atopy in Puerto Rican children. |
| title_fullStr | Mouse allergen, lung function, and atopy in Puerto Rican children. |
| title_full_unstemmed | Mouse allergen, lung function, and atopy in Puerto Rican children. |
| title_short | Mouse allergen, lung function, and atopy in Puerto Rican children. |
| title_sort | mouse allergen lung function and atopy in puerto rican children |
| url | http://europepmc.org/articles/PMC3398035?pdf=render |
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