Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations
The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disc degeneration results in degradation of disc solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00004/full |
| _version_ | 1819231665007886336 |
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| author | Mohammad eNikkhoo Mohammad eNikkhoo Kinda eKhalaf Ya-Wen eKuo Yu-Chun eHsu Mohammad eHaghpanahi Mohamad eParnianpour Jaw-Lin eWang |
| author_facet | Mohammad eNikkhoo Mohammad eNikkhoo Kinda eKhalaf Ya-Wen eKuo Yu-Chun eHsu Mohammad eHaghpanahi Mohamad eParnianpour Jaw-Lin eWang |
| author_sort | Mohammad eNikkhoo |
| collection | DOAJ |
| description | The risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disc degeneration results in degradation of disc solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid-fluid interactions of degenerative discs to cyclic loadings are not well studied yet. The fluid-solid interactions in discs can be evaluated by mathematical models, especially the poroelastic finite element models. We developed a robust disc poroelastic FE model to analyze the effect of degeneration on solid-fluid interactions within disc subjected to cyclic loadings at different loading frequencies. A backward analysis combined with in-vitro experiments were used to find the elastic modulus and hydraulic permeability of intact and enzyme-induced degenerated porcine discs. The results showed that the averaged peak-to-peak disc deformations during the in-vitro cyclic tests were well fitted with limited FE simulations and a quadratic response surface regression for both disc groups. The results showed that higher loading frequency increased the intradiscal pressure, decreased the total fluid loss, and slightly increased the maximum axial stress within solid matrix. Enzyme-induced degeneration decreased the intradiscal pressure and total fluid loss, and barely changed the maximum axial stress within solid matrix. The increase of intradiscal pressure and total fluid loss with loading frequency was less sensitive after the frequency elevated to 0.1 Hz for the enzyme-induced degenerated disc. Based on this study, it is found that enzyme-induced degeneration decreases energy attenuation capability of disc, but less change the strength of disc. |
| first_indexed | 2024-12-23T11:48:34Z |
| format | Article |
| id | doaj.art-a3cf703f4b8a4f9d8a6944c54d008b04 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-23T11:48:34Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a3cf703f4b8a4f9d8a6944c54d008b042022-12-21T17:48:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852015-01-01310.3389/fbioe.2015.00004119092Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element SimulationsMohammad eNikkhoo0Mohammad eNikkhoo1Kinda eKhalaf2Ya-Wen eKuo3Yu-Chun eHsu4Mohammad eHaghpanahi5Mohamad eParnianpour6Jaw-Lin eWang7Science and Research Branch, Islamic Azad UniversityNational Taiwan UniversityKhalifa University of Science, Technology and ResearchNational Taiwan UniversityNational Taiwan UniversityIran University of Science and TechnologyUniversity of WisconsinNational Taiwan UniversityThe risk of low back pain resulted from cyclic loadings is greater than that resulted from prolonged static postures. Disc degeneration results in degradation of disc solid structures and decrease of water contents, which is caused by activation of matrix digestive enzymes. The mechanical responses resulted from internal solid-fluid interactions of degenerative discs to cyclic loadings are not well studied yet. The fluid-solid interactions in discs can be evaluated by mathematical models, especially the poroelastic finite element models. We developed a robust disc poroelastic FE model to analyze the effect of degeneration on solid-fluid interactions within disc subjected to cyclic loadings at different loading frequencies. A backward analysis combined with in-vitro experiments were used to find the elastic modulus and hydraulic permeability of intact and enzyme-induced degenerated porcine discs. The results showed that the averaged peak-to-peak disc deformations during the in-vitro cyclic tests were well fitted with limited FE simulations and a quadratic response surface regression for both disc groups. The results showed that higher loading frequency increased the intradiscal pressure, decreased the total fluid loss, and slightly increased the maximum axial stress within solid matrix. Enzyme-induced degeneration decreased the intradiscal pressure and total fluid loss, and barely changed the maximum axial stress within solid matrix. The increase of intradiscal pressure and total fluid loss with loading frequency was less sensitive after the frequency elevated to 0.1 Hz for the enzyme-induced degenerated disc. Based on this study, it is found that enzyme-induced degeneration decreases energy attenuation capability of disc, but less change the strength of disc.http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00004/fullResponse Surface MethodologyPoroelastic FE modelPorcine intervertebral discFluid-Solid InteractionArtificial degeneration |
| spellingShingle | Mohammad eNikkhoo Mohammad eNikkhoo Kinda eKhalaf Ya-Wen eKuo Yu-Chun eHsu Mohammad eHaghpanahi Mohamad eParnianpour Jaw-Lin eWang Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations Frontiers in Bioengineering and Biotechnology Response Surface Methodology Poroelastic FE model Porcine intervertebral disc Fluid-Solid Interaction Artificial degeneration |
| title | Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations |
| title_full | Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations |
| title_fullStr | Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations |
| title_full_unstemmed | Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations |
| title_short | Effect of Degeneration on Fluid-Solid Interaction within Intervertebral Disc under Cyclic Loading – A Meta-Model Analysis of Finite Element Simulations |
| title_sort | effect of degeneration on fluid solid interaction within intervertebral disc under cyclic loading a meta model analysis of finite element simulations |
| topic | Response Surface Methodology Poroelastic FE model Porcine intervertebral disc Fluid-Solid Interaction Artificial degeneration |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00004/full |
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