Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects
Arterial hypertension and dyslipidemia is a very frequent comorbid condition. Arterial hypertension and dyslipidemia are combined in 40-70% of patients. The statins is the basic drug in primary and secondary prevention of cardiovascular disease and in the reduction of cardiovascular complications. W...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IP Morozov P.V.
2017-12-01
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| Series: | Системные гипертензии |
| Subjects: | |
| Online Access: | https://syst-hypertension.ru/2075-082X/article/viewFile/29590/pdf |
| _version_ | 1818308384972079104 |
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| author | E V Luchinina O G Kompaniets N V Kizhvatova |
| author_facet | E V Luchinina O G Kompaniets N V Kizhvatova |
| author_sort | E V Luchinina |
| collection | DOAJ |
| description | Arterial hypertension and dyslipidemia is a very frequent comorbid condition. Arterial hypertension and dyslipidemia are combined in 40-70% of patients. The statins is the basic drug in primary and secondary prevention of cardiovascular disease and in the reduction of cardiovascular complications. We`ve attempted to summarize some data about the statins and interaction of antihypertensive drugs. Rosuvastatin is a medicine that provides an intensive reduction of low-density lipoproteins, does not require dose adjustment when applied in conjunction with antihypertensive drugs. The absence of inhibition and activation of rosuvastatin cytochrome P450 provides a low risk of negative interactions in the clinical situations of induced polypharmacy. Every clinician is to remember that it`s crucial to take into account some adverse reactions combining the statins with drugs of other pharmacological groups. |
| first_indexed | 2024-12-13T07:13:26Z |
| format | Article |
| id | doaj.art-a3d04c8705864b0cb543a8019398dd0d |
| institution | Directory Open Access Journal |
| issn | 2075-082X 2542-2189 |
| language | Russian |
| last_indexed | 2024-12-13T07:13:26Z |
| publishDate | 2017-12-01 |
| publisher | IP Morozov P.V. |
| record_format | Article |
| series | Системные гипертензии |
| spelling | doaj.art-a3d04c8705864b0cb543a8019398dd0d2022-12-21T23:55:37ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892017-12-01143798310.26442/2075-082X_14.3.79-8326618Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospectsE V Luchinina0O G Kompaniets1N V Kizhvatova2V.I.Razumovsky Saratov State Medical University of the Ministry of Health of the Russian FederationKuban State Medical University of the Ministry of Health of the Russian FederationKuban State Medical University of the Ministry of Health of the Russian FederationArterial hypertension and dyslipidemia is a very frequent comorbid condition. Arterial hypertension and dyslipidemia are combined in 40-70% of patients. The statins is the basic drug in primary and secondary prevention of cardiovascular disease and in the reduction of cardiovascular complications. We`ve attempted to summarize some data about the statins and interaction of antihypertensive drugs. Rosuvastatin is a medicine that provides an intensive reduction of low-density lipoproteins, does not require dose adjustment when applied in conjunction with antihypertensive drugs. The absence of inhibition and activation of rosuvastatin cytochrome P450 provides a low risk of negative interactions in the clinical situations of induced polypharmacy. Every clinician is to remember that it`s crucial to take into account some adverse reactions combining the statins with drugs of other pharmacological groups.https://syst-hypertension.ru/2075-082X/article/viewFile/29590/pdfdyslipidemiarosuvastatinantihypertensive drugs |
| spellingShingle | E V Luchinina O G Kompaniets N V Kizhvatova Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects Системные гипертензии dyslipidemia rosuvastatin antihypertensive drugs |
| title | Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects |
| title_full | Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects |
| title_fullStr | Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects |
| title_full_unstemmed | Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects |
| title_short | Interaction of antihypertensive drugs and rosuvastatin: focus on safety, efficiency and prospects |
| title_sort | interaction of antihypertensive drugs and rosuvastatin focus on safety efficiency and prospects |
| topic | dyslipidemia rosuvastatin antihypertensive drugs |
| url | https://syst-hypertension.ru/2075-082X/article/viewFile/29590/pdf |
| work_keys_str_mv | AT evluchinina interactionofantihypertensivedrugsandrosuvastatinfocusonsafetyefficiencyandprospects AT ogkompaniets interactionofantihypertensivedrugsandrosuvastatinfocusonsafetyefficiencyandprospects AT nvkizhvatova interactionofantihypertensivedrugsandrosuvastatinfocusonsafetyefficiencyandprospects |