Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome
The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.
Bibliographic Details
| Main Authors: |
Daniel Fox,
Anukriti Mathur,
Yansong Xue,
Yunqi Liu,
Wei Hong Tan,
Shouya Feng,
Abhimanu Pandey,
Chinh Ngo,
Jenni A. Hayward,
Ines I. Atmosukarto,
Jason D. Price,
Matthew D. Johnson,
Nadja Jessberger,
Avril A. B. Robertson,
Gaetan Burgio,
David C. Tscharke,
Edward M. Fox,
Denisse L. Leyton,
Nadeem O. Kaakoush,
Erwin Märtlbauer,
Stephen H. Leppla,
Si Ming Man |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14534-3
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