Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation.

Bibliographic Details
Main Authors: Daniel Fox, Anukriti Mathur, Yansong Xue, Yunqi Liu, Wei Hong Tan, Shouya Feng, Abhimanu Pandey, Chinh Ngo, Jenni A. Hayward, Ines I. Atmosukarto, Jason D. Price, Matthew D. Johnson, Nadja Jessberger, Avril A. B. Robertson, Gaetan Burgio, David C. Tscharke, Edward M. Fox, Denisse L. Leyton, Nadeem O. Kaakoush, Erwin Märtlbauer, Stephen H. Leppla, Si Ming Man
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14534-3

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