Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening

In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ingredients (API). The isomeric pyridinecarboxami...

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Bibliographic Details
Main Authors: João A. Baptista, Mário T. S. Rosado, Ricardo A. E. Castro, António O. L. Évora, Teresa M. R. Maria, Manuela Ramos Silva, João Canotilho, M. Ermelinda S. Eusébio
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
co-crystal screening
dihydrofolate reductase inhibitors
pharmacophore
trimethoprim
pyrimethamine
2,4-diaminopyrimidine
Online Access:https://www.mdpi.com/1420-3049/26/21/6721

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