Neuroprotective Potential of Biflavone Ginkgetin: A Review
Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkg...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/562 |
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| author | İ. İrem Tatlı Çankaya Hari Prasad Devkota Gokhan Zengin Dunja Šamec |
| author_facet | İ. İrem Tatlı Çankaya Hari Prasad Devkota Gokhan Zengin Dunja Šamec |
| author_sort | İ. İrem Tatlı Çankaya |
| collection | DOAJ |
| description | Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (<i>Ginkgo biloba</i> L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted. |
| first_indexed | 2024-03-11T08:32:41Z |
| format | Article |
| id | doaj.art-a3d2c24756e14fb59c6214d8ebaa1ddf |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:41Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-a3d2c24756e14fb59c6214d8ebaa1ddf2023-11-16T21:42:58ZengMDPI AGLife2075-17292023-02-0113256210.3390/life13020562Neuroprotective Potential of Biflavone Ginkgetin: A Reviewİ. İrem Tatlı Çankaya0Hari Prasad Devkota1Gokhan Zengin2Dunja Šamec3Department of Pharmaceutical Botany, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyGraduate School of Pharmaceutical Sciences, Kumamoto University, Chuo-ku, Kumamoto 862-0973, JapanDepartment of Biology, Science Faculty, Selcuk University, 42130 Konya, TurkeyDepartment of Food Technology, University Center Koprivnica, University North, 48000 Koprivnica, CroatiaNeurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results. Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (<i>Ginkgo biloba</i> L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer’s disease (AD), and Parkinson’s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity. Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where ginkgetin showed promising results, and further clinical studies should be conducted.https://www.mdpi.com/2075-1729/13/2/562Alzheimer’s diseasebiflavonoidsginkgetinneuroprotectionginkgo |
| spellingShingle | İ. İrem Tatlı Çankaya Hari Prasad Devkota Gokhan Zengin Dunja Šamec Neuroprotective Potential of Biflavone Ginkgetin: A Review Life Alzheimer’s disease biflavonoids ginkgetin neuroprotection ginkgo |
| title | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| title_full | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| title_fullStr | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| title_full_unstemmed | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| title_short | Neuroprotective Potential of Biflavone Ginkgetin: A Review |
| title_sort | neuroprotective potential of biflavone ginkgetin a review |
| topic | Alzheimer’s disease biflavonoids ginkgetin neuroprotection ginkgo |
| url | https://www.mdpi.com/2075-1729/13/2/562 |
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