Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications

Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications

HIV-1 Tat plays a critical role in viral transactivation. Subtype-B Tat has potential use as a therapeutic vaccine. However, viral genetic diversity and population genetics would significantly impact the efficacy of such a vaccine. Over 70% of the 37-million HIV-infected individuals are in sub-Sahar...

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Bibliographic Details
Main Authors: Georges Teto, Julius Y. Fonsah, Claude T. Tagny, Dora Mbanya, Emilienne Nchindap, Leopoldine Kenmogne, Joseph Fokam, Dora M. Njamnshi, Charles Kouanfack, Alfred K. Njamnshi, Georgette D. Kanmogne
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Viruses
Subjects:
Cameroon
Tat exon-1
HIV-1 genetic diversity
N-myristoylation
amidation
casein kinase-2
phosphorylation
HLA binding sites
Online Access:http://www.mdpi.com/1999-4915/8/7/196

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