Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?
Abstract Background The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease. Methods A retrospective study of 392 patients diagnosed wit...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Urology |
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| Online Access: | http://link.springer.com/article/10.1186/s12894-018-0365-0 |
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| author | Ronald Wagner Pereira Coelho Jaqueline Diniz Pinho Janise Silva Moreno Dimitrius Vidal e Oliveira Garbis Athiene Maniva Teixeira do Nascimento Joyce Santos Larges José Ribamar Rodrigues Calixto Leandra Naira Zambelli Ramalho Antônio Augusto Moura da Silva Leudivan Ribeiro Nogueira Laisson de Moura Feitoza Gyl Eanes Barros Silva |
| author_facet | Ronald Wagner Pereira Coelho Jaqueline Diniz Pinho Janise Silva Moreno Dimitrius Vidal e Oliveira Garbis Athiene Maniva Teixeira do Nascimento Joyce Santos Larges José Ribamar Rodrigues Calixto Leandra Naira Zambelli Ramalho Antônio Augusto Moura da Silva Leudivan Ribeiro Nogueira Laisson de Moura Feitoza Gyl Eanes Barros Silva |
| author_sort | Ronald Wagner Pereira Coelho |
| collection | DOAJ |
| description | Abstract Background The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease. Methods A retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004–2014. Results The age-standardized incidence was 6.15 per 100,000 and the crude annual incidence was 1.18 per 100,000. More than half (61.1%) of the tumors were histological grades 2 and 3, and 66.4% of tumors were classified as at least stage T2. The average age of patients was 58.6 ± 15.7 years (range, 18 to 103 years), with 20.8% of patients ≤40 years of age at diagnosis. The vast majority underwent penectomy (93%). Only 41.8% underwent lymphadenectomy, 58 patients (14.8%) received chemotherapy, and 54 patients (13.8%) received radiotherapy. Stage 3/4 and vascular invasion were statically significant at disease-free survival analysis. Conclusion The state of Maranhão has the highest incidence of penile cancer in Brazil and globally. Tumors are locally advanced and at the time of diagnosis, and there is a high frequency among young individuals. Patients have a low socioeconomic status, making it difficult to complete treatment and receive appropriate follow-up. |
| first_indexed | 2024-04-11T23:54:23Z |
| format | Article |
| id | doaj.art-a3d3a055d19146ce82c23890f18b5c0b |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-11T23:54:23Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-a3d3a055d19146ce82c23890f18b5c0b2022-12-22T03:56:24ZengBMCBMC Urology1471-24902018-05-011811710.1186/s12894-018-0365-0Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally?Ronald Wagner Pereira Coelho0Jaqueline Diniz Pinho1Janise Silva Moreno2Dimitrius Vidal e Oliveira Garbis3Athiene Maniva Teixeira do Nascimento4Joyce Santos Larges5José Ribamar Rodrigues Calixto6Leandra Naira Zambelli Ramalho7Antônio Augusto Moura da Silva8Leudivan Ribeiro Nogueira9Laisson de Moura Feitoza10Gyl Eanes Barros Silva11Aldenora Bello Cancer HospitalFederal University of ParáAldenora Bello Cancer HospitalFederal University of MaranhãoFederal University of MaranhãoUniversity Hospital of Federal University of MaranhãoFederal University of MaranhãoDepartment of Radiology and Pathology, Ribeirão Preto Medical School of University of São PauloPublic Heath Departament, Federal University of MaranhãoAldenora Bello Cancer HospitalFederal University of MaranhãoUniversity Hospital of Federal University of MaranhãoAbstract Background The objectives of this study were to determine the minimum incidence of penile cancer in the poorest Brazilian state, and to describe the epidemiologic and clinical characteristics of patients diagnosed with the disease. Methods A retrospective study of 392 patients diagnosed with penile cancer in the three most important referral center in the state was conducted during 2004–2014. Results The age-standardized incidence was 6.15 per 100,000 and the crude annual incidence was 1.18 per 100,000. More than half (61.1%) of the tumors were histological grades 2 and 3, and 66.4% of tumors were classified as at least stage T2. The average age of patients was 58.6 ± 15.7 years (range, 18 to 103 years), with 20.8% of patients ≤40 years of age at diagnosis. The vast majority underwent penectomy (93%). Only 41.8% underwent lymphadenectomy, 58 patients (14.8%) received chemotherapy, and 54 patients (13.8%) received radiotherapy. Stage 3/4 and vascular invasion were statically significant at disease-free survival analysis. Conclusion The state of Maranhão has the highest incidence of penile cancer in Brazil and globally. Tumors are locally advanced and at the time of diagnosis, and there is a high frequency among young individuals. Patients have a low socioeconomic status, making it difficult to complete treatment and receive appropriate follow-up.http://link.springer.com/article/10.1186/s12894-018-0365-0CarcinomaPenis cancerAge-standardized incidencePenectomySquamous cell carcinoma |
| spellingShingle | Ronald Wagner Pereira Coelho Jaqueline Diniz Pinho Janise Silva Moreno Dimitrius Vidal e Oliveira Garbis Athiene Maniva Teixeira do Nascimento Joyce Santos Larges José Ribamar Rodrigues Calixto Leandra Naira Zambelli Ramalho Antônio Augusto Moura da Silva Leudivan Ribeiro Nogueira Laisson de Moura Feitoza Gyl Eanes Barros Silva Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? BMC Urology Carcinoma Penis cancer Age-standardized incidence Penectomy Squamous cell carcinoma |
| title | Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? |
| title_full | Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? |
| title_fullStr | Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? |
| title_full_unstemmed | Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? |
| title_short | Penile cancer in Maranhão, Northeast Brazil: the highest incidence globally? |
| title_sort | penile cancer in maranhao northeast brazil the highest incidence globally |
| topic | Carcinoma Penis cancer Age-standardized incidence Penectomy Squamous cell carcinoma |
| url | http://link.springer.com/article/10.1186/s12894-018-0365-0 |
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