Low-Molecular-Weight Heparin-Functionalized Chitosan-Chondroitin Sulfate Hydrogels for Controlled Release of TGF-β3 and in vitro Neocartilage Formation

Low-Molecular-Weight Heparin-Functionalized Chitosan-Chondroitin Sulfate Hydrogels for Controlled Release of TGF-β3 and in vitro Neocartilage Formation

Repair of hyaline cartilage remains a huge challenge in clinic because of the avascular and aneural characteristics and the paucity of endogenous repair cells. Recently, tissue engineering technique, possessing unique capacity of repairing large tissue defects, avoiding donor complications and two-s...

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Bibliographic Details
Main Authors: You-Rong Chen, Zhu-Xing Zhou, Ji-Ying Zhang, Fu-Zhen Yuan, Bing-Bing Xu, Jian Guan, Chao Han, Dong Jiang, Yan-Yu Yang, Jia-Kuo Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
low-molecular-weight heparin
hydrogel
controlled release
peripheral blood mesenchymal stem cell
tissue-engineered cartilage
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00745/full

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