Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury

Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury

Chronic kidney disease (CKD), which is associated with high morbidity, remains a worldwide health concern, while effective therapies remain limited. Hydroxychloroquine (HCQ), which mainly targets toll-like receptor-7 (TLR-7) and TLR-9, is associated with a lower risk of incident CKD. Taking into acc...

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Bibliographic Details
Main Authors: Haofeng Zheng, Yannan Zhang, Jiannan He, Zhe Yang, Rui Zhang, Lei Li, Zihuan Luo, Yongrong Ye, Qiquan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
hydroxychloroquine
chronic kidney disease
fibrosis
macrophage
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645100/full

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