Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population
Objective: To determine whether obesity, physical fitness, and physical activity parameters are associated with the enzymatic activity of serum dipeptidyl peptidase IV (sDPPIV) in a sample of healthy women and men. Design and methods: We have correlated parameters of obesity, physical fitness, and p...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018304456 |
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| author | B. Sanz G. Larrinaga A. Fernandez-Atucha J. Gil A.B. Fraile-Bermudez M. Kortajarena A. Izagirre P. Martinez-Lage J. Irazusta |
| author_facet | B. Sanz G. Larrinaga A. Fernandez-Atucha J. Gil A.B. Fraile-Bermudez M. Kortajarena A. Izagirre P. Martinez-Lage J. Irazusta |
| author_sort | B. Sanz |
| collection | DOAJ |
| description | Objective: To determine whether obesity, physical fitness, and physical activity parameters are associated with the enzymatic activity of serum dipeptidyl peptidase IV (sDPPIV) in a sample of healthy women and men.
Design and methods: We have correlated parameters of obesity, physical fitness, and physical activity with sDPPIV activity in 374 healthy subjects (age: 60.7 ± 6.9 years, body mass index: 26.1 ± 4.1 kg/m2). Enzymatic activity was analyzed using spectrofluorimetry, body composition was assessed by impedanciometry, physical fitness data were obtained using the Senior Fitness Test, and physical activity data were collected by accelerometer. Pearson's partial correlation analysis was applied to determine the relationship between DPPIV activity and the rest of parameters and significantly correlated variables were introduced into linear regression models to predict DPPIV.
Results: Serum DPPIV activity was negatively associated with obesity parameters such as body mass (r = −0.112), body mass index (BMI) (r = −0.147), waist circumference (r = −0.164), waist-to-hip ratio (−0.104), and percentage of fat mass (r = −0.185). Serum DPPIV activity was positively associated with cardiovascular fitness (r = 0.138), total amount of physical activity (r = 0.153), and time spent doing light exercise (r = 0.184). Regression models revealed sex differences in enzyme activity with overall activity higher in women than in men (β = 0.437, p < 0.001). Further, percent fat mass was an independent negative predictor of DPPIV activity (β = −0.184, p = 0.001). Serum DPPIV activity was positively predicted based on the amount of time spent doing light physical activity (β = 0.167, p = 0.001).
Conclusion: Our results demonstrate that sDPPIV activity is positively associated with healthier parameters regarding fatness, fitness and physical activity. |
| first_indexed | 2024-12-21T07:45:18Z |
| format | Article |
| id | doaj.art-a3d6445df2df451faf5b7ed68d4f94d7 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-21T07:45:18Z |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a3d6445df2df451faf5b7ed68d4f94d72022-12-21T19:11:12ZengElsevierHeliyon2405-84402018-05-014510.1016/j.heliyon.2018.e00627Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy populationB. Sanz0G. Larrinaga1A. Fernandez-Atucha2J. Gil3A.B. Fraile-Bermudez4M. Kortajarena5A. Izagirre6P. Martinez-Lage7J. Irazusta8Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bizkaia, SpainBioCruces Health Research Institute, Barakaldo, Bizkaia, SpainDepartment of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bizkaia, SpainDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bizkaia, SpainDepartment of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bizkaia, SpainDepartment of Nursing II, Faculty of Medicine and Nursing, University of the Basque Country, Donostia, Gipuzkoa, SpainDepartment of Nursing II, Faculty of Medicine and Nursing, University of the Basque Country, Donostia, Gipuzkoa, SpainDepartment of Neurology, CITA-Alzheimer Foundation, San Sebastian, SpainDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bizkaia, SpainObjective: To determine whether obesity, physical fitness, and physical activity parameters are associated with the enzymatic activity of serum dipeptidyl peptidase IV (sDPPIV) in a sample of healthy women and men. Design and methods: We have correlated parameters of obesity, physical fitness, and physical activity with sDPPIV activity in 374 healthy subjects (age: 60.7 ± 6.9 years, body mass index: 26.1 ± 4.1 kg/m2). Enzymatic activity was analyzed using spectrofluorimetry, body composition was assessed by impedanciometry, physical fitness data were obtained using the Senior Fitness Test, and physical activity data were collected by accelerometer. Pearson's partial correlation analysis was applied to determine the relationship between DPPIV activity and the rest of parameters and significantly correlated variables were introduced into linear regression models to predict DPPIV. Results: Serum DPPIV activity was negatively associated with obesity parameters such as body mass (r = −0.112), body mass index (BMI) (r = −0.147), waist circumference (r = −0.164), waist-to-hip ratio (−0.104), and percentage of fat mass (r = −0.185). Serum DPPIV activity was positively associated with cardiovascular fitness (r = 0.138), total amount of physical activity (r = 0.153), and time spent doing light exercise (r = 0.184). Regression models revealed sex differences in enzyme activity with overall activity higher in women than in men (β = 0.437, p < 0.001). Further, percent fat mass was an independent negative predictor of DPPIV activity (β = −0.184, p = 0.001). Serum DPPIV activity was positively predicted based on the amount of time spent doing light physical activity (β = 0.167, p = 0.001). Conclusion: Our results demonstrate that sDPPIV activity is positively associated with healthier parameters regarding fatness, fitness and physical activity.http://www.sciencedirect.com/science/article/pii/S2405844018304456MetabolismPhysiologyEndocrinology |
| spellingShingle | B. Sanz G. Larrinaga A. Fernandez-Atucha J. Gil A.B. Fraile-Bermudez M. Kortajarena A. Izagirre P. Martinez-Lage J. Irazusta Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population Heliyon Metabolism Physiology Endocrinology |
| title | Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population |
| title_full | Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population |
| title_fullStr | Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population |
| title_full_unstemmed | Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population |
| title_short | Obesity parameters, physical activity, and physical fitness are correlated with serum dipeptidyl peptidase IV activity in a healthy population |
| title_sort | obesity parameters physical activity and physical fitness are correlated with serum dipeptidyl peptidase iv activity in a healthy population |
| topic | Metabolism Physiology Endocrinology |
| url | http://www.sciencedirect.com/science/article/pii/S2405844018304456 |
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