Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression

Abstracts Background Many neurological diseases involve neuroinflammation, during which overproduction of cytokines by immune cells, especially microglia, can aggregate neuronal death. Ferroptosis is a recently discovered cell metabolism-related form of cell death and RSL3 is a well-known inducer of...

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Bibliographic Details
Main Authors: Yu Cui, Zhaolong Zhang, Xin Zhou, Zhiyuan Zhao, Rui Zhao, Xiangyu Xu, Xiangyi Kong, Jinyang Ren, Xujin Yao, Qian Wen, Feifei Guo, Shengli Gao, Jiangdong Sun, Qi Wan
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Neuroinflammation
Subjects:
Ferroptosis
RSL3
Neuroinflammation
Microglia
Macrophage
LPS
Online Access:https://doi.org/10.1186/s12974-021-02231-x

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