APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression

Abstract Background Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pat...

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Bibliographic Details
Main Authors: Noha-Ehssan Mohamed, Trevor Hay, Karen R. Reed, Matthew J. Smalley, Alan R. Clarke
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
APC2
APC hypomorph
WNT signalling
Ovarian fertility
Ovarian cancer
Granulosa cell tumour
Online Access:http://link.springer.com/article/10.1186/s12885-019-5867-y

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