Clinical Implications of Circulating Circular RNAs in Lung Cancer
Circular RNAs (circRNAs) are single-stranded RNAs with a covalently closed-loop structure that increases their stability; thus, they are more advantageous to use as liquid biopsy markers than linear RNAs. circRNAs are thought to be generated by back-splicing of pre-mRNA transcripts, which can be fac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/871 |
| _version_ | 1797436768420626432 |
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| author | Sae Seul Choi Sae Eun Kim Seon Young Oh Young-Ho Ahn |
| author_facet | Sae Seul Choi Sae Eun Kim Seon Young Oh Young-Ho Ahn |
| author_sort | Sae Seul Choi |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are single-stranded RNAs with a covalently closed-loop structure that increases their stability; thus, they are more advantageous to use as liquid biopsy markers than linear RNAs. circRNAs are thought to be generated by back-splicing of pre-mRNA transcripts, which can be facilitated by reverse complementary sequences in the flanking introns and trans-acting factors, such as splicing regulatory factors and RNA-binding factors. circRNAs function as miRNA sponges, interact with target proteins, regulate the stability and translatability of other mRNAs, regulate gene expression, and produce microproteins. circRNAs are also found in the body fluids of cancer patients, including plasma, saliva, urine, and cerebrospinal fluid, and these “circulating circRNAs” can be used as cancer biomarkers. In lung cancer, some circulating circRNAs have been reported to regulate cancer progression and drug resistance. Circulating circRNAs have significant diagnostic value and are associated with the prognosis of lung cancer patients. Owing to their functional versatility, heightened stability, and practical applicability, circulating circRNAs represent promising biomarkers for lung cancer diagnosis, prognosis, and treatment monitoring. |
| first_indexed | 2024-03-09T11:07:22Z |
| format | Article |
| id | doaj.art-a3dda247403b499dad4262869d5be582 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:07:22Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a3dda247403b499dad4262869d5be5822023-12-01T00:54:38ZengMDPI AGBiomedicines2227-90592022-04-0110487110.3390/biomedicines10040871Clinical Implications of Circulating Circular RNAs in Lung CancerSae Seul Choi0Sae Eun Kim1Seon Young Oh2Young-Ho Ahn3Department of Medicine, College of Medicine, Ewha Womans University, Seoul 07804, KoreaDepartment of Medicine, College of Medicine, Ewha Womans University, Seoul 07804, KoreaDepartment of Molecular Medicine, Ewha Womans University, Seoul 07804, KoreaDepartment of Medicine, College of Medicine, Ewha Womans University, Seoul 07804, KoreaCircular RNAs (circRNAs) are single-stranded RNAs with a covalently closed-loop structure that increases their stability; thus, they are more advantageous to use as liquid biopsy markers than linear RNAs. circRNAs are thought to be generated by back-splicing of pre-mRNA transcripts, which can be facilitated by reverse complementary sequences in the flanking introns and trans-acting factors, such as splicing regulatory factors and RNA-binding factors. circRNAs function as miRNA sponges, interact with target proteins, regulate the stability and translatability of other mRNAs, regulate gene expression, and produce microproteins. circRNAs are also found in the body fluids of cancer patients, including plasma, saliva, urine, and cerebrospinal fluid, and these “circulating circRNAs” can be used as cancer biomarkers. In lung cancer, some circulating circRNAs have been reported to regulate cancer progression and drug resistance. Circulating circRNAs have significant diagnostic value and are associated with the prognosis of lung cancer patients. Owing to their functional versatility, heightened stability, and practical applicability, circulating circRNAs represent promising biomarkers for lung cancer diagnosis, prognosis, and treatment monitoring.https://www.mdpi.com/2227-9059/10/4/871circular RNAslung cancerliquid biopsydiagnosisprognosis |
| spellingShingle | Sae Seul Choi Sae Eun Kim Seon Young Oh Young-Ho Ahn Clinical Implications of Circulating Circular RNAs in Lung Cancer Biomedicines circular RNAs lung cancer liquid biopsy diagnosis prognosis |
| title | Clinical Implications of Circulating Circular RNAs in Lung Cancer |
| title_full | Clinical Implications of Circulating Circular RNAs in Lung Cancer |
| title_fullStr | Clinical Implications of Circulating Circular RNAs in Lung Cancer |
| title_full_unstemmed | Clinical Implications of Circulating Circular RNAs in Lung Cancer |
| title_short | Clinical Implications of Circulating Circular RNAs in Lung Cancer |
| title_sort | clinical implications of circulating circular rnas in lung cancer |
| topic | circular RNAs lung cancer liquid biopsy diagnosis prognosis |
| url | https://www.mdpi.com/2227-9059/10/4/871 |
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