Newborn amygdala connectivity and early emerging fear
Connectivity between the amygdala, insula (Amygdala-aI) and ventral medial prefrontal cortex (Amygdala-vmPFC) have been implicated in individual variability in fear and vulnerability to psychiatric disorders. However, it is currently unknown to what extent connectivity between these regions in the n...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
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| Series: | Developmental Cognitive Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929318301658 |
| _version_ | 1831518708134051840 |
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| author | Elina Thomas Claudia Buss Jerod M. Rasmussen Sonja Entringer Julian S.B. Ramirez Mollie Marr Marc D. Rudolph John H. Gilmore Martin Styner Pathik D. Wadhwa Damien A. Fair Alice M. Graham |
| author_facet | Elina Thomas Claudia Buss Jerod M. Rasmussen Sonja Entringer Julian S.B. Ramirez Mollie Marr Marc D. Rudolph John H. Gilmore Martin Styner Pathik D. Wadhwa Damien A. Fair Alice M. Graham |
| author_sort | Elina Thomas |
| collection | DOAJ |
| description | Connectivity between the amygdala, insula (Amygdala-aI) and ventral medial prefrontal cortex (Amygdala-vmPFC) have been implicated in individual variability in fear and vulnerability to psychiatric disorders. However, it is currently unknown to what extent connectivity between these regions in the newborn period is relevant for the development of fear and other aspects of negative emotionality (NE), such as sadness. Here, we investigate newborn Am-Ins and Am-vmPFC resting state functional connectivity in relation to developmental trajectories of fear and sadness over the first two years of life using data from the Infant Behavior Questionnaire Revised (IBQ-R) and Early Childhood Behavior Questionnaire (ECBQ) (N=62). Stronger newborn amygdala connectivity predicts higher fear and sadness at 6-months-of-age and less change from 6 to 24-months-of-age. Interestingly, Am-Ins connectivity was specifically relevant for fear and not sadness, while Am-vmPFC was associated only with sadness. Associations remained consistent after considering variation in maternal sensitivity and maternal postnatal depressive symptomology. Already by the time of birth, individual differences in amygdala connectivity are relevant for the expression of fear over the first two-years-of-life. Additionally, specificity is observed, such that connections relevant for fear development are distinct from those predicting sadness trajectories. Keywords: Amygdala, Fear, Sadness, Infancy, Resting state fMRI, Development |
| first_indexed | 2024-12-13T08:54:06Z |
| format | Article |
| id | doaj.art-a3ddee4d0a41462cb28ba84333e31585 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-13T08:54:06Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-a3ddee4d0a41462cb28ba84333e315852022-12-21T23:53:19ZengElsevierDevelopmental Cognitive Neuroscience1878-92932019-06-0137Newborn amygdala connectivity and early emerging fearElina Thomas0Claudia Buss1Jerod M. Rasmussen2Sonja Entringer3Julian S.B. Ramirez4Mollie Marr5Marc D. Rudolph6John H. Gilmore7Martin Styner8Pathik D. Wadhwa9Damien A. Fair10Alice M. Graham11Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USACharité –Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA, USACharité –Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, GermanyCharité –Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USADepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USADepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USACharité –Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, GermanyDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA; Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USADepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; Corresponding author.Connectivity between the amygdala, insula (Amygdala-aI) and ventral medial prefrontal cortex (Amygdala-vmPFC) have been implicated in individual variability in fear and vulnerability to psychiatric disorders. However, it is currently unknown to what extent connectivity between these regions in the newborn period is relevant for the development of fear and other aspects of negative emotionality (NE), such as sadness. Here, we investigate newborn Am-Ins and Am-vmPFC resting state functional connectivity in relation to developmental trajectories of fear and sadness over the first two years of life using data from the Infant Behavior Questionnaire Revised (IBQ-R) and Early Childhood Behavior Questionnaire (ECBQ) (N=62). Stronger newborn amygdala connectivity predicts higher fear and sadness at 6-months-of-age and less change from 6 to 24-months-of-age. Interestingly, Am-Ins connectivity was specifically relevant for fear and not sadness, while Am-vmPFC was associated only with sadness. Associations remained consistent after considering variation in maternal sensitivity and maternal postnatal depressive symptomology. Already by the time of birth, individual differences in amygdala connectivity are relevant for the expression of fear over the first two-years-of-life. Additionally, specificity is observed, such that connections relevant for fear development are distinct from those predicting sadness trajectories. Keywords: Amygdala, Fear, Sadness, Infancy, Resting state fMRI, Developmenthttp://www.sciencedirect.com/science/article/pii/S1878929318301658 |
| spellingShingle | Elina Thomas Claudia Buss Jerod M. Rasmussen Sonja Entringer Julian S.B. Ramirez Mollie Marr Marc D. Rudolph John H. Gilmore Martin Styner Pathik D. Wadhwa Damien A. Fair Alice M. Graham Newborn amygdala connectivity and early emerging fear Developmental Cognitive Neuroscience |
| title | Newborn amygdala connectivity and early emerging fear |
| title_full | Newborn amygdala connectivity and early emerging fear |
| title_fullStr | Newborn amygdala connectivity and early emerging fear |
| title_full_unstemmed | Newborn amygdala connectivity and early emerging fear |
| title_short | Newborn amygdala connectivity and early emerging fear |
| title_sort | newborn amygdala connectivity and early emerging fear |
| url | http://www.sciencedirect.com/science/article/pii/S1878929318301658 |
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