The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat
In a previous report, we found neurons with ON-OFF and OFF-ON firing activity in the obex reticular formation during scratching. The aim of the present study was to examine whether the spinal neurons also exhibit this type of activity in relation to the “postural stage” of fictive scratching in the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2018.00068/full |
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| author | Carlos A. Cuellar Braniff De La Torre Valdovinos Nayeli Huidobro Rodolfo Delgado-Lezama Rafael Ornelas-Kobayashi Elias Manjarrez |
| author_facet | Carlos A. Cuellar Braniff De La Torre Valdovinos Nayeli Huidobro Rodolfo Delgado-Lezama Rafael Ornelas-Kobayashi Elias Manjarrez |
| author_sort | Carlos A. Cuellar |
| collection | DOAJ |
| description | In a previous report, we found neurons with ON-OFF and OFF-ON firing activity in the obex reticular formation during scratching. The aim of the present study was to examine whether the spinal neurons also exhibit this type of activity in relation to the “postural stage” of fictive scratching in the cat. We found that the extensor and intermediate scratching neurons exhibit an ON-OFF firing rate; conversely, the flexor neurons show an OFF-ON activity, relative to every scratching episode. These patterns of spiking activity are similar to those found in neurons from the obex reticular formation during scratching. Our findings provide support to the following hypotheses. First, there is a possible functional link between supraspinal and spinal, ON-OFF and OFF-ON neuronal groups. Second, the fictive goal-directed motor action to maintain the fictive “postural stage” of the hindlimb during fictive scratching is associated with the neuronal tonic activity of the OFF-ON spinal neurons, whereas the ON-OFF spinal neurons are associated with an extensor tone that occurred prior the postural stage. |
| first_indexed | 2024-12-11T03:28:00Z |
| format | Article |
| id | doaj.art-a3de106ca2b04248bd8518eff7a10183 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T03:28:00Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-a3de106ca2b04248bd8518eff7a101832022-12-22T01:22:27ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-03-011210.3389/fncel.2018.00068322525The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the CatCarlos A. Cuellar0Braniff De La Torre Valdovinos1Nayeli Huidobro2Rodolfo Delgado-Lezama3Rafael Ornelas-Kobayashi4Elias Manjarrez5Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, United StatesCentro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, MexicoInstituto de Fisiología, Benemerita Universidad Autonoma de Puebla, Puebla, MexicoDepartamento de Fisiologia, Biofisica y Neurociencias, CINVESTAV IPN, Mexico City, MexicoUniversity of Groningen, Groningen, NetherlandsInstituto de Fisiología, Benemerita Universidad Autonoma de Puebla, Puebla, MexicoIn a previous report, we found neurons with ON-OFF and OFF-ON firing activity in the obex reticular formation during scratching. The aim of the present study was to examine whether the spinal neurons also exhibit this type of activity in relation to the “postural stage” of fictive scratching in the cat. We found that the extensor and intermediate scratching neurons exhibit an ON-OFF firing rate; conversely, the flexor neurons show an OFF-ON activity, relative to every scratching episode. These patterns of spiking activity are similar to those found in neurons from the obex reticular formation during scratching. Our findings provide support to the following hypotheses. First, there is a possible functional link between supraspinal and spinal, ON-OFF and OFF-ON neuronal groups. Second, the fictive goal-directed motor action to maintain the fictive “postural stage” of the hindlimb during fictive scratching is associated with the neuronal tonic activity of the OFF-ON spinal neurons, whereas the ON-OFF spinal neurons are associated with an extensor tone that occurred prior the postural stage.http://journal.frontiersin.org/article/10.3389/fncel.2018.00068/fullCPGspinal cordfictive scratchingflexor phaseinterneuronsfiring rate |
| spellingShingle | Carlos A. Cuellar Braniff De La Torre Valdovinos Nayeli Huidobro Rodolfo Delgado-Lezama Rafael Ornelas-Kobayashi Elias Manjarrez The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat Frontiers in Cellular Neuroscience CPG spinal cord fictive scratching flexor phase interneurons firing rate |
| title | The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat |
| title_full | The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat |
| title_fullStr | The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat |
| title_full_unstemmed | The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat |
| title_short | The Spinal Neurons Exhibit an ON-OFF and OFF-ON Firing Activity Around the Onset of Fictive Scratching Episodes in the Cat |
| title_sort | spinal neurons exhibit an on off and off on firing activity around the onset of fictive scratching episodes in the cat |
| topic | CPG spinal cord fictive scratching flexor phase interneurons firing rate |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2018.00068/full |
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