Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units
Background: The increasing cases of carbapenemase resistant Enterobacteriaceae (CRE) across the world is a cause of concern. Asymptomatic carriage of CRE in critical care units is a menace to infection control. Aims: This study determines the carriage rate of CRE in patients admitted to the intensiv...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Saudi Journal for Health Sciences |
| Subjects: | |
| Online Access: | http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2023;volume=12;issue=1;spage=43;epage=48;aulast=Raju |
| _version_ | 1797866378232856576 |
|---|---|
| author | Kevin Thevarmadam Raju Thomas S Kuruvilla Sharon Joseph |
| author_facet | Kevin Thevarmadam Raju Thomas S Kuruvilla Sharon Joseph |
| author_sort | Kevin Thevarmadam Raju |
| collection | DOAJ |
| description | Background: The increasing cases of carbapenemase resistant Enterobacteriaceae (CRE) across the world is a cause of concern. Asymptomatic carriage of CRE in critical care units is a menace to infection control. Aims: This study determines the carriage rate of CRE in patients admitted to the intensive care units (ICU's) and evaluates the potential risk factors, leading to colonization in patients with CRE. Materials and Methods: Sixty rectal swabs from patients in the ICU's were screened for carriage of CRE. The samples were inoculated onto ChromID CARBA SMART bi-plate. The organisms showing color appearances as per the manufacturer's instructions were considered as CRE. Routine disk diffusion technique was also employed and CRE was defined as an organism belonging to the Enterobacteriaceae family which was resistant to either imipenem or meropenem. Results: The organisms isolated were identified and the percentage of carriage of carbapenem-resistant organisms was 12 (20%), of which Klebsiella pneumoniae was 4 (33.3%), Escherichia coli 6 (50%), Citrobacter freundii 1 (8.3%), and Enterobacter spp. 1 (8.3%). Out of these, 2 (3.3%) showed OXA 48 type resistance seen with K. pneumoniae and E. coli. Prior hospitalization, the use of high-end antibiotics and patients who have undergone surgeries were the most common potential risk factors for colonization with CRE. Conclusion: The prompt detection of CRE by routine screening using cost-effective methods and reduction of potential risk factors for gut colonization reduce the transmission of drug resistance in any hospital setting and pave the way for better antibiotic stewardship and appropriate contact isolation precautions. |
| first_indexed | 2024-04-09T23:24:21Z |
| format | Article |
| id | doaj.art-a3de38f1846d445ba7778fecd1a8934c |
| institution | Directory Open Access Journal |
| issn | 2278-0521 |
| language | English |
| last_indexed | 2024-04-09T23:24:21Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal for Health Sciences |
| spelling | doaj.art-a3de38f1846d445ba7778fecd1a8934c2023-03-21T11:27:27ZengWolters Kluwer Medknow PublicationsSaudi Journal for Health Sciences2278-05212023-01-01121434810.4103/sjhs.sjhs_143_22Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care unitsKevin Thevarmadam RajuThomas S KuruvillaSharon JosephBackground: The increasing cases of carbapenemase resistant Enterobacteriaceae (CRE) across the world is a cause of concern. Asymptomatic carriage of CRE in critical care units is a menace to infection control. Aims: This study determines the carriage rate of CRE in patients admitted to the intensive care units (ICU's) and evaluates the potential risk factors, leading to colonization in patients with CRE. Materials and Methods: Sixty rectal swabs from patients in the ICU's were screened for carriage of CRE. The samples were inoculated onto ChromID CARBA SMART bi-plate. The organisms showing color appearances as per the manufacturer's instructions were considered as CRE. Routine disk diffusion technique was also employed and CRE was defined as an organism belonging to the Enterobacteriaceae family which was resistant to either imipenem or meropenem. Results: The organisms isolated were identified and the percentage of carriage of carbapenem-resistant organisms was 12 (20%), of which Klebsiella pneumoniae was 4 (33.3%), Escherichia coli 6 (50%), Citrobacter freundii 1 (8.3%), and Enterobacter spp. 1 (8.3%). Out of these, 2 (3.3%) showed OXA 48 type resistance seen with K. pneumoniae and E. coli. Prior hospitalization, the use of high-end antibiotics and patients who have undergone surgeries were the most common potential risk factors for colonization with CRE. Conclusion: The prompt detection of CRE by routine screening using cost-effective methods and reduction of potential risk factors for gut colonization reduce the transmission of drug resistance in any hospital setting and pave the way for better antibiotic stewardship and appropriate contact isolation precautions.http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2023;volume=12;issue=1;spage=43;epage=48;aulast=Rajuasymptomatic carriagecarbapenemaseenterobacteriaceaeresistancescreening |
| spellingShingle | Kevin Thevarmadam Raju Thomas S Kuruvilla Sharon Joseph Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units Saudi Journal for Health Sciences asymptomatic carriage carbapenemase enterobacteriaceae resistance screening |
| title | Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units |
| title_full | Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units |
| title_fullStr | Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units |
| title_full_unstemmed | Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units |
| title_short | Screening for carriers of carbapenemase producing Enterobacteriaceae in critical care units |
| title_sort | screening for carriers of carbapenemase producing enterobacteriaceae in critical care units |
| topic | asymptomatic carriage carbapenemase enterobacteriaceae resistance screening |
| url | http://www.saudijhealthsci.org/article.asp?issn=2278-0521;year=2023;volume=12;issue=1;spage=43;epage=48;aulast=Raju |
| work_keys_str_mv | AT kevinthevarmadamraju screeningforcarriersofcarbapenemaseproducingenterobacteriaceaeincriticalcareunits AT thomasskuruvilla screeningforcarriersofcarbapenemaseproducingenterobacteriaceaeincriticalcareunits AT sharonjoseph screeningforcarriersofcarbapenemaseproducingenterobacteriaceaeincriticalcareunits |