Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid

Engineering of Escherichia coli for Krebs cycle-dependent production of malic acid

Abstract Background Malate is a C4-dicarboxylic acid widely used as an acidulant in the food and beverage industry. Rational engineering has been performed in the past for the development of microbial strains capable of efficient production of this metabolite. However, as malate can be a precursor f...

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Bibliographic Details
Main Authors: Debora Trichez, Clément Auriol, Audrey Baylac, Romain Irague, Clémentine Dressaire, Marc Carnicer-Heras, Stéphanie Heux, Jean Marie François, Thomas Walther
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Microbial Cell Factories
Subjects:
Malic acid
Escherichia coli
Flux analysis
Metabolic engineering
Online Access:http://link.springer.com/article/10.1186/s12934-018-0959-y

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