Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and a...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/8/9451 |
| Summary: | Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and antileishmanial activity against erythrocytic forms of <em>Plasmodium falciparum</em> and axenic forms of <em>Leishmania infantum</em>. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against <em>Plasmodium</em>, but two of them showed good activity against <em>Leishmania</em>. Toxicity on VERO was correlated with leishmanicidal properties. |
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| ISSN: | 1420-3049 |