Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/8/9451 |
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| author | Carlos Barea Adriana Pabón Silvia Galiano Silvia Pérez-Silanes German Gonzalez Chloe Deyssard Antonio Monge Eric Deharo Ignacio Aldana |
| author_facet | Carlos Barea Adriana Pabón Silvia Galiano Silvia Pérez-Silanes German Gonzalez Chloe Deyssard Antonio Monge Eric Deharo Ignacio Aldana |
| author_sort | Carlos Barea |
| collection | DOAJ |
| description | Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and antileishmanial activity against erythrocytic forms of <em>Plasmodium falciparum</em> and axenic forms of <em>Leishmania infantum</em>. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against <em>Plasmodium</em>, but two of them showed good activity against <em>Leishmania</em>. Toxicity on VERO was correlated with leishmanicidal properties. |
| first_indexed | 2024-12-11T22:22:34Z |
| format | Article |
| id | doaj.art-a3de6a7503684163842193463dd1f163 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T22:22:34Z |
| publishDate | 2012-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a3de6a7503684163842193463dd1f1632022-12-22T00:48:24ZengMDPI AGMolecules1420-30492012-08-011789451946110.3390/molecules17089451Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide DerivativesCarlos BareaAdriana PabónSilvia GalianoSilvia Pérez-SilanesGerman GonzalezChloe DeyssardAntonio MongeEric DeharoIgnacio AldanaMalaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their <em>in vitro</em> antimalarial and antileishmanial activity against erythrocytic forms of <em>Plasmodium falciparum</em> and axenic forms of <em>Leishmania infantum</em>. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against <em>Plasmodium</em>, but two of them showed good activity against <em>Leishmania</em>. Toxicity on VERO was correlated with leishmanicidal properties.http://www.mdpi.com/1420-3049/17/8/9451quinoxalinepiperazine<em>Plasmodium</em><em>Leishmania</em>VERO |
| spellingShingle | Carlos Barea Adriana Pabón Silvia Galiano Silvia Pérez-Silanes German Gonzalez Chloe Deyssard Antonio Monge Eric Deharo Ignacio Aldana Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives Molecules quinoxaline piperazine <em>Plasmodium</em> <em>Leishmania</em> VERO |
| title | Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives |
| title_full | Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives |
| title_fullStr | Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives |
| title_full_unstemmed | Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives |
| title_short | Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives |
| title_sort | antiplasmodial and leishmanicidal activities of 2 cyano 3 4 phenylpiperazine 1 carboxamido quinoxaline 1 4 dioxide derivatives |
| topic | quinoxaline piperazine <em>Plasmodium</em> <em>Leishmania</em> VERO |
| url | http://www.mdpi.com/1420-3049/17/8/9451 |
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