Metabolic alterations in meningioma reflect the clinical course
Abstract Background Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their World Health Organization (WHO) grade. The current study aimed to identif...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-07887-5 |
| _version_ | 1823927055644884992 |
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| author | Waseem Masalha Karam Daka Jakob Woerner Nils Pompe Stefan Weber Daniel Delev Marie T. Krüger Oliver Schnell Jürgen Beck Dieter Henrik Heiland Juergen Grauvogel |
| author_facet | Waseem Masalha Karam Daka Jakob Woerner Nils Pompe Stefan Weber Daniel Delev Marie T. Krüger Oliver Schnell Jürgen Beck Dieter Henrik Heiland Juergen Grauvogel |
| author_sort | Waseem Masalha |
| collection | DOAJ |
| description | Abstract Background Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their World Health Organization (WHO) grade. The current study aimed to identify potential markers that can discriminate between benign and malignant meningioma courses. Methods We profiled the metabolites from 43 patients with low- and high-grade meningiomas. Tumour specimens were analyzed by nuclear magnetic resonance analysis; 270 metabolites were identified and clustered with the AutoPipe algorithm. Results We observed two distinct clusters marked by alterations in glycine/serine and choline/tryptophan metabolism. Glycine/serine cluster showed significantly lower WHO grades and proliferation rates. Also progression-free survival was significantly longer in the glycine/serine cluster. Conclusion Our findings suggest that alterations in glycine/serine metabolism are associated with lower proliferation and more recurrent tumours. Altered choline/tryptophan metabolism was associated with increases proliferation, and recurrence. Our results suggest that tumour malignancy can be reflected by metabolic alterations, which may support histological classifications to predict the clinical outcome of patients with meningiomas. |
| first_indexed | 2024-12-16T20:33:32Z |
| format | Article |
| id | doaj.art-a3e0a86df9f54702bfdc85b9982ad874 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T20:33:32Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a3e0a86df9f54702bfdc85b9982ad8742022-12-21T22:17:21ZengBMCBMC Cancer1471-24072021-03-012111910.1186/s12885-021-07887-5Metabolic alterations in meningioma reflect the clinical courseWaseem Masalha0Karam Daka1Jakob Woerner2Nils Pompe3Stefan Weber4Daniel Delev5Marie T. Krüger6Oliver Schnell7Jürgen Beck8Dieter Henrik Heiland9Juergen Grauvogel10Department of Neurosurgery, University Medical Center FreiburgDepartment of Neurosurgery, University Medical Center FreiburgInstitute of Physical Chemistry, Faculty of Chemistry and Pharmacy, University of FreiburgInstitute of Physical Chemistry, Faculty of Chemistry and Pharmacy, University of FreiburgInstitute of Physical Chemistry, Faculty of Chemistry and Pharmacy, University of FreiburgDepartment of Neurosurgery, RWTH UniversityDepartment of Neurosurgery, Cantonal Hospital St.GallenDepartment of Neurosurgery, University Medical Center FreiburgDepartment of Neurosurgery, University Medical Center FreiburgDepartment of Neurosurgery, University Medical Center FreiburgDepartment of Neurosurgery, University Medical Center FreiburgAbstract Background Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their World Health Organization (WHO) grade. The current study aimed to identify potential markers that can discriminate between benign and malignant meningioma courses. Methods We profiled the metabolites from 43 patients with low- and high-grade meningiomas. Tumour specimens were analyzed by nuclear magnetic resonance analysis; 270 metabolites were identified and clustered with the AutoPipe algorithm. Results We observed two distinct clusters marked by alterations in glycine/serine and choline/tryptophan metabolism. Glycine/serine cluster showed significantly lower WHO grades and proliferation rates. Also progression-free survival was significantly longer in the glycine/serine cluster. Conclusion Our findings suggest that alterations in glycine/serine metabolism are associated with lower proliferation and more recurrent tumours. Altered choline/tryptophan metabolism was associated with increases proliferation, and recurrence. Our results suggest that tumour malignancy can be reflected by metabolic alterations, which may support histological classifications to predict the clinical outcome of patients with meningiomas.https://doi.org/10.1186/s12885-021-07887-5Tumour metabolismMeningioma |
| spellingShingle | Waseem Masalha Karam Daka Jakob Woerner Nils Pompe Stefan Weber Daniel Delev Marie T. Krüger Oliver Schnell Jürgen Beck Dieter Henrik Heiland Juergen Grauvogel Metabolic alterations in meningioma reflect the clinical course BMC Cancer Tumour metabolism Meningioma |
| title | Metabolic alterations in meningioma reflect the clinical course |
| title_full | Metabolic alterations in meningioma reflect the clinical course |
| title_fullStr | Metabolic alterations in meningioma reflect the clinical course |
| title_full_unstemmed | Metabolic alterations in meningioma reflect the clinical course |
| title_short | Metabolic alterations in meningioma reflect the clinical course |
| title_sort | metabolic alterations in meningioma reflect the clinical course |
| topic | Tumour metabolism Meningioma |
| url | https://doi.org/10.1186/s12885-021-07887-5 |
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