Seeking genetic determinants of selected metabolic disorders in women aged 45–60
Introduction and objective The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, an...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2020-09-01
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| Series: | Annals of Agricultural and Environmental Medicine |
| Subjects: | |
| Online Access: | http://www.aaem.pl/Seeking-genetic-determinants-of-selected-metabolic-disorders-in-women-aged-45-60,112579,0,2.html |
| _version_ | 1818392520820785152 |
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| author | Małgorzata Szkup Jacek Brodowski Anna Jurczak Marzanna Stanisławska Elżbieta Grochans |
| author_facet | Małgorzata Szkup Jacek Brodowski Anna Jurczak Marzanna Stanisławska Elżbieta Grochans |
| author_sort | Małgorzata Szkup |
| collection | DOAJ |
| description | Introduction and objective
The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, and the presence of the PPAR-γ rs1801282, the FTO rs9939609, and the MC4R rs17782313 polymorphisms in women aged 45–60.
Material and methods
The study included 425 women, aged 45–59 years, from the general population of the West Pomeranian Province in north-west Poland. The research procedure involved a structured interview, anthropometric and blood pressure measurements, biochemical analysis of serum, and genetic analysis.
Results
The carriers of the A/A genotype of the FTO polymorphism had higher LDL levels than their counterparts with the T/T genotype (p = 0.01). The carriers of the T/T genotype of the MC4R polymorphism had lower non-HDL levels than those with the C/C and C/T genotypes (p = 0.019). Weight was related to the C/C and the C/G + G/G genotypes of the PPAR-γ gene polymorphism (p = 0.046). The model of inheritance for the MC4R polymorphism had a significant effect on TG (p = 0.039) and non-HDL (p = 0.05) levels.
Conclusions
The genotypes analyzed in the study had only a slight direct effect on the biochemical and anthropometric
abnormalities typical of metabolic disorders. Nonetheless, the risk alleles (A allele of the FTO rs9939609 and the C allele of the MC4R rs17782313) were found to be related to lipid metabolism disorders in 45–60-year-old women. |
| first_indexed | 2024-12-14T05:30:44Z |
| format | Article |
| id | doaj.art-a3e0bba931aa4d4b98d0ce14b743ed41 |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-14T05:30:44Z |
| publishDate | 2020-09-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-a3e0bba931aa4d4b98d0ce14b743ed412022-12-21T23:15:20ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632020-09-0127340741210.26444/aaem/112579112579Seeking genetic determinants of selected metabolic disorders in women aged 45–60Małgorzata Szkup0Jacek Brodowski1Anna Jurczak2Marzanna Stanisławska3Elżbieta Grochans4Department of Nursing, Pomeranian Medical University, Szczecin, PolandPrimary Care Department, Pomeranian Medical University, Szczecin, PolandDepartment of Clinical Nursing, Pomeranian Medical University, Szczecin, PolandDepartment of Nursing, Pomeranian Medical University, Szczecin, PolandDepartment of Nursing, Pomeranian Medical University, Szczecin, PolandIntroduction and objective The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, and the presence of the PPAR-γ rs1801282, the FTO rs9939609, and the MC4R rs17782313 polymorphisms in women aged 45–60. Material and methods The study included 425 women, aged 45–59 years, from the general population of the West Pomeranian Province in north-west Poland. The research procedure involved a structured interview, anthropometric and blood pressure measurements, biochemical analysis of serum, and genetic analysis. Results The carriers of the A/A genotype of the FTO polymorphism had higher LDL levels than their counterparts with the T/T genotype (p = 0.01). The carriers of the T/T genotype of the MC4R polymorphism had lower non-HDL levels than those with the C/C and C/T genotypes (p = 0.019). Weight was related to the C/C and the C/G + G/G genotypes of the PPAR-γ gene polymorphism (p = 0.046). The model of inheritance for the MC4R polymorphism had a significant effect on TG (p = 0.039) and non-HDL (p = 0.05) levels. Conclusions The genotypes analyzed in the study had only a slight direct effect on the biochemical and anthropometric abnormalities typical of metabolic disorders. Nonetheless, the risk alleles (A allele of the FTO rs9939609 and the C allele of the MC4R rs17782313) were found to be related to lipid metabolism disorders in 45–60-year-old women.http://www.aaem.pl/Seeking-genetic-determinants-of-selected-metabolic-disorders-in-women-aged-45-60,112579,0,2.htmlgenesmetabolic syndrome xppar gamma |
| spellingShingle | Małgorzata Szkup Jacek Brodowski Anna Jurczak Marzanna Stanisławska Elżbieta Grochans Seeking genetic determinants of selected metabolic disorders in women aged 45–60 Annals of Agricultural and Environmental Medicine genes metabolic syndrome x ppar gamma |
| title | Seeking genetic determinants of selected metabolic disorders in women aged 45–60 |
| title_full | Seeking genetic determinants of selected metabolic disorders in women aged 45–60 |
| title_fullStr | Seeking genetic determinants of selected metabolic disorders in women aged 45–60 |
| title_full_unstemmed | Seeking genetic determinants of selected metabolic disorders in women aged 45–60 |
| title_short | Seeking genetic determinants of selected metabolic disorders in women aged 45–60 |
| title_sort | seeking genetic determinants of selected metabolic disorders in women aged 45 60 |
| topic | genes metabolic syndrome x ppar gamma |
| url | http://www.aaem.pl/Seeking-genetic-determinants-of-selected-metabolic-disorders-in-women-aged-45-60,112579,0,2.html |
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