High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway
Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored th...
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MDPI AG
2020-02-01
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| Online Access: | https://www.mdpi.com/2079-7737/9/2/24 |
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| author | Bo-Ram Jin Kyung-Sook Chung Minho Lee Hyo-Jin An |
| author_facet | Bo-Ram Jin Kyung-Sook Chung Minho Lee Hyo-Jin An |
| author_sort | Bo-Ram Jin |
| collection | DOAJ |
| description | Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored this relationship. We established an HFD-fed colitis-associated colon cancer (CAC) mice model and evaluated the anti-tumorigenic effects of AG on HFD-propelled CAC along with its mechanism of action. Previously, we found that <i>Aster glehni</i> (AG) exerts chemopreventive effects on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC in a mice model, and has anti-adipogenic effects in a HFD-induced obesity mice model. In the HFD-propelled CAC mice model, AG significantly reduced cancer-related death, prevented body weight loss, and alleviated splenic enlargement. Additionally, AG prevented colon shortening and reduced the number of colorectal polyps. Histological studies demonstrated the up-regulation of inflammation, hyperplasia, and neoplasia in HFD-propelled CAC mice, whereas AG suppressed colonic disease progression and tumorigenesis. Furthermore, AG significantly inhibited the signal transducer and activator of transcription 3 (STAT3) signaling pathway and attenuated the protein expression of the STAT3 target gene, which mediates transcription factor-dependent tumor cell proliferation. These results indicate that AG abrogates inflammation-induced tumor progression in HFD-propelled CAC mice by inhibiting STAT3 activation. |
| first_indexed | 2024-03-12T08:14:07Z |
| format | Article |
| id | doaj.art-a3e121e73a214056ac9d74ddab7f0946 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T08:14:07Z |
| publishDate | 2020-02-01 |
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| record_format | Article |
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| spelling | doaj.art-a3e121e73a214056ac9d74ddab7f09462023-09-02T19:02:15ZengMDPI AGBiology2079-77372020-02-01922410.3390/biology9020024biology9020024High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling PathwayBo-Ram Jin0Kyung-Sook Chung1Minho Lee2Hyo-Jin An3Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, KoreaDepartment of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, KoreaCatholic Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, 222, Banpodaero, Seocho-gu, Seoul 06591, KoreaDepartment of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju-si, Gangwon-do 26339, KoreaMany epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have not explored this relationship. We established an HFD-fed colitis-associated colon cancer (CAC) mice model and evaluated the anti-tumorigenic effects of AG on HFD-propelled CAC along with its mechanism of action. Previously, we found that <i>Aster glehni</i> (AG) exerts chemopreventive effects on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CAC in a mice model, and has anti-adipogenic effects in a HFD-induced obesity mice model. In the HFD-propelled CAC mice model, AG significantly reduced cancer-related death, prevented body weight loss, and alleviated splenic enlargement. Additionally, AG prevented colon shortening and reduced the number of colorectal polyps. Histological studies demonstrated the up-regulation of inflammation, hyperplasia, and neoplasia in HFD-propelled CAC mice, whereas AG suppressed colonic disease progression and tumorigenesis. Furthermore, AG significantly inhibited the signal transducer and activator of transcription 3 (STAT3) signaling pathway and attenuated the protein expression of the STAT3 target gene, which mediates transcription factor-dependent tumor cell proliferation. These results indicate that AG abrogates inflammation-induced tumor progression in HFD-propelled CAC mice by inhibiting STAT3 activation.https://www.mdpi.com/2079-7737/9/2/24high-fat dietcolitis-associated colon cancerinflammation<i>aster glehni</i> |
| spellingShingle | Bo-Ram Jin Kyung-Sook Chung Minho Lee Hyo-Jin An High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway Biology high-fat diet colitis-associated colon cancer inflammation <i>aster glehni</i> |
| title | High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway |
| title_full | High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway |
| title_fullStr | High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway |
| title_full_unstemmed | High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway |
| title_short | High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of <i>Aster glehni</i> via STAT3 Signaling Pathway |
| title_sort | high fat diet propelled aom dss induced colitis associated colon cancer alleviated by administration of i aster glehni i via stat3 signaling pathway |
| topic | high-fat diet colitis-associated colon cancer inflammation <i>aster glehni</i> |
| url | https://www.mdpi.com/2079-7737/9/2/24 |
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