Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
The nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11390 |
| _version_ | 1818427123929448448 |
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| author | Emilien Nicolas Pascaline Parisot Celina Pinto-Monteiro Roxane de Walque Christophe De Vleeschouwer Denis L. J. Lafontaine |
| author_facet | Emilien Nicolas Pascaline Parisot Celina Pinto-Monteiro Roxane de Walque Christophe De Vleeschouwer Denis L. J. Lafontaine |
| author_sort | Emilien Nicolas |
| collection | DOAJ |
| description | The nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the nucleolus and p53 homeostasis. |
| first_indexed | 2024-12-14T14:40:44Z |
| format | Article |
| id | doaj.art-a3e1be32abf34328a408ce075cdfbd0f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:40:44Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a3e1be32abf34328a408ce075cdfbd0f2022-12-21T22:57:25ZengNature PortfolioNature Communications2041-17232016-06-017111210.1038/ncomms11390Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stressEmilien Nicolas0Pascaline Parisot1Celina Pinto-Monteiro2Roxane de Walque3Christophe De Vleeschouwer4Denis L. J. Lafontaine5RNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesICTEAM-ELEN, Université catholique de LouvainRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesICTEAM-ELEN, Université catholique de LouvainRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesThe nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the nucleolus and p53 homeostasis.https://doi.org/10.1038/ncomms11390 |
| spellingShingle | Emilien Nicolas Pascaline Parisot Celina Pinto-Monteiro Roxane de Walque Christophe De Vleeschouwer Denis L. J. Lafontaine Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress Nature Communications |
| title | Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress |
| title_full | Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress |
| title_fullStr | Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress |
| title_full_unstemmed | Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress |
| title_short | Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress |
| title_sort | involvement of human ribosomal proteins in nucleolar structure and p53 dependent nucleolar stress |
| url | https://doi.org/10.1038/ncomms11390 |
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