The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients
ABSTRACTObjectives Multiple myeloma (MM) is a malignant disease characterized by a single clonal proliferation of B cell-derived plasma cells in the bone marrow. It is the second most common haematologic malignancy in adults. The objective of this retrospective study is to evaluate the diagnostic an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2023.2240145 |
| _version_ | 1797771985139269632 |
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| author | Fuyan Han Nan Sheng Chenchen Sheng Jing Meng |
| author_facet | Fuyan Han Nan Sheng Chenchen Sheng Jing Meng |
| author_sort | Fuyan Han |
| collection | DOAJ |
| description | ABSTRACTObjectives Multiple myeloma (MM) is a malignant disease characterized by a single clonal proliferation of B cell-derived plasma cells in the bone marrow. It is the second most common haematologic malignancy in adults. The objective of this retrospective study is to evaluate the diagnostic and prognostic value of haematologic parameters in MM.Methods The difference of NLR/ALB ratio (NAR) and NLR/HDL-C ratio (NHR) between the 151 newly diagnosed MM patients and 153 healthy controls was compared. According to NAR and NHR cutoff values obtained from the ROC curve, MM patients were divided into low group and high group. The differences in hematological parameters and survival time between the two groups were compared. Independent prognostic analysis was performed using Cox proportional hazard regression model.Results The NAR and NHR values in MM group were significantly higher than those in control group (P < 0.001). Higher NAR levels were significantly associated with lower albumin (ALB), higher β2 microglobulin(β2-MG), higher creatinine (Crea), and highe ISS stage (All P<0.05). High NHR group was significantly correlated with age , β2-MG and ISS stage (All P<0.05). In high NAR or NHR groups, OS and DFS was significantly shortened and the prognosis was poor (P < 0.05). Multivariate analysis showed that PLT, ISS stage and NAR were independent prognostic indicators of OS in MM patients, while ALB, PLT and NAR were independent prognostic factors of DFS.Conclusion NAR and NHR are inexpensive, readily available diagnostic indicators for MM, and NAR is an independent prognostic factor for MM. |
| first_indexed | 2024-03-12T21:44:32Z |
| format | Article |
| id | doaj.art-a3e204ba577c48a4bf4ecb3056b398ff |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-03-12T21:44:32Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj.art-a3e204ba577c48a4bf4ecb3056b398ff2023-07-26T13:05:24ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2023.2240145The diagnostic and prognostic value of haematologic parameters in multiple myeloma patientsFuyan Han0Nan Sheng1Chenchen Sheng2Jing Meng3Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, People’s Republic of ChinaDepartment of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, People’s Republic of ChinaDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, People’s Republic of ChinaDepartment of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, People’s Republic of ChinaABSTRACTObjectives Multiple myeloma (MM) is a malignant disease characterized by a single clonal proliferation of B cell-derived plasma cells in the bone marrow. It is the second most common haematologic malignancy in adults. The objective of this retrospective study is to evaluate the diagnostic and prognostic value of haematologic parameters in MM.Methods The difference of NLR/ALB ratio (NAR) and NLR/HDL-C ratio (NHR) between the 151 newly diagnosed MM patients and 153 healthy controls was compared. According to NAR and NHR cutoff values obtained from the ROC curve, MM patients were divided into low group and high group. The differences in hematological parameters and survival time between the two groups were compared. Independent prognostic analysis was performed using Cox proportional hazard regression model.Results The NAR and NHR values in MM group were significantly higher than those in control group (P < 0.001). Higher NAR levels were significantly associated with lower albumin (ALB), higher β2 microglobulin(β2-MG), higher creatinine (Crea), and highe ISS stage (All P<0.05). High NHR group was significantly correlated with age , β2-MG and ISS stage (All P<0.05). In high NAR or NHR groups, OS and DFS was significantly shortened and the prognosis was poor (P < 0.05). Multivariate analysis showed that PLT, ISS stage and NAR were independent prognostic indicators of OS in MM patients, while ALB, PLT and NAR were independent prognostic factors of DFS.Conclusion NAR and NHR are inexpensive, readily available diagnostic indicators for MM, and NAR is an independent prognostic factor for MM.https://www.tandfonline.com/doi/10.1080/16078454.2023.2240145Multiple myelomaNLRNARNHRALBHDL-C |
| spellingShingle | Fuyan Han Nan Sheng Chenchen Sheng Jing Meng The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients Hematology Multiple myeloma NLR NAR NHR ALB HDL-C |
| title | The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| title_full | The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| title_fullStr | The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| title_full_unstemmed | The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| title_short | The diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| title_sort | diagnostic and prognostic value of haematologic parameters in multiple myeloma patients |
| topic | Multiple myeloma NLR NAR NHR ALB HDL-C |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2023.2240145 |
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