ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly
In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development o...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2020-03-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/6/1/00350-2019.full |
| _version_ | 1818277226435575808 |
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| author | Niki D. Ubags Jonathan Baker Agnes Boots Rita Costa Natalia El-Merhie Aurélie Fabre Alen Faiz Irene H. Heijink Pieter S. Hiemstra Mareike Lehmann Silke Meiners Sara Rolandsson Enes Sabine Bartel |
| author_facet | Niki D. Ubags Jonathan Baker Agnes Boots Rita Costa Natalia El-Merhie Aurélie Fabre Alen Faiz Irene H. Heijink Pieter S. Hiemstra Mareike Lehmann Silke Meiners Sara Rolandsson Enes Sabine Bartel |
| author_sort | Niki D. Ubags |
| collection | DOAJ |
| description | In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine. |
| first_indexed | 2024-12-12T22:58:10Z |
| format | Article |
| id | doaj.art-a3e221c0f796463080e812242fda442e |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-12T22:58:10Z |
| publishDate | 2020-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-a3e221c0f796463080e812242fda442e2022-12-22T00:08:54ZengEuropean Respiratory SocietyERJ Open Research2312-05412020-03-016110.1183/23120541.00350-201900350-2019ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science AssemblyNiki D. Ubags0Jonathan Baker1Agnes Boots2Rita Costa3Natalia El-Merhie4Aurélie Fabre5Alen Faiz6Irene H. Heijink7Pieter S. Hiemstra8Mareike Lehmann9Silke Meiners10Sara Rolandsson Enes11Sabine Bartel12 Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, Lausanne, Switzerland Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK Dept of Pharmacology and Toxicology, Maastricht University, Maastricht, the Netherlands Lung Repair and Regeneration Unit, Helmholtz-Zentrum Munich, Ludwig-Maximilians-University, University Hospital Grosshadern, Member of the German Center of Lung Research (DZL), Munich, Germany Early Life Origins of Chronic Lung Disease, Research Center Borstel, Leibniz Lung Center, Member of the DZL and the Airway Research Center North (ARCN), Borstel, Germany St Vincent's University Hospital, Dublin, Ireland University of Technology Sydney, Respiratory Bioinformatics and Molecular Biology (RBMB), School of Life Sciences, Sydney, Australia University of Groningen, University Medical Center Groningen, Depts of Pathology & Medical Biology and Pulmonology, Groningen, The Netherlands Dept of Pulmonology, Leiden University Medical Center (LUMC), Leiden, The Netherlands Lung Repair and Regeneration Unit, Helmholtz-Zentrum Munich, Ludwig-Maximilians-University, University Hospital Grosshadern, Member of the German Center of Lung Research (DZL), Munich, Germany Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the DZL, Munich, Germany University of Vermont, Dept of Medicine, Larner College of Medicine, Burlington, VT, USA University of Groningen, University Medical Center Groningen, Depts of Pathology & Medical Biology and Pulmonology, Groningen, The Netherlands In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.http://openres.ersjournals.com/content/6/1/00350-2019.full |
| spellingShingle | Niki D. Ubags Jonathan Baker Agnes Boots Rita Costa Natalia El-Merhie Aurélie Fabre Alen Faiz Irene H. Heijink Pieter S. Hiemstra Mareike Lehmann Silke Meiners Sara Rolandsson Enes Sabine Bartel ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly ERJ Open Research |
| title | ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly |
| title_full | ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly |
| title_fullStr | ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly |
| title_full_unstemmed | ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly |
| title_short | ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly |
| title_sort | ers international congress madrid 2019 highlights from the basic and translational science assembly |
| url | http://openres.ersjournals.com/content/6/1/00350-2019.full |
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