BELATACEPT IN RENAL TRANSPLANTATION
Belatacept is a novel immunosuppressive agent that inhibits T-cell activation by blocking CD28 signaling pa- thway. It was developed based on abatacept (CTLA-4Ig), the first recombinant immunoglobulin fusion protein which contains extracellular part of CTLA-4 molecule and Fc domain of IgG. First cli...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2013-03-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/146 |
| _version_ | 1797872160950190080 |
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| author | A. I. Sushkov Y. G. Moysyuk |
| author_facet | A. I. Sushkov Y. G. Moysyuk |
| author_sort | A. I. Sushkov |
| collection | DOAJ |
| description | Belatacept is a novel immunosuppressive agent that inhibits T-cell activation by blocking CD28 signaling pa- thway. It was developed based on abatacept (CTLA-4Ig), the first recombinant immunoglobulin fusion protein which contains extracellular part of CTLA-4 molecule and Fc domain of IgG. First clinical trials have shown the comparable patient and graft survival in group of kidney recipients with belatacept-based maintenance im- munosuppressive therapy versus Cyclosporin A-based therapy. Advantages observed with belatacept include superior glomerular filtration rate and improved cardiovascular risk profile. Belatacept is a potential option for maintenance immunosuppressive therapy without calcineurin inhibitors. Concerns associated with belatacept use are higher rates of acute cellular rejection episodes and post-transplant lymphoproliferative disorder cases. |
| first_indexed | 2024-04-10T00:54:27Z |
| format | Article |
| id | doaj.art-a3e25f1abb6d4c15b848b4084873e165 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:54:27Z |
| publishDate | 2013-03-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-a3e25f1abb6d4c15b848b4084873e1652023-03-13T10:37:18ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912013-03-011519610510.15825/1995-1191-2013-1-96-10589BELATACEPT IN RENAL TRANSPLANTATIONA. I. Sushkov0Y. G. Moysyuk1Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow I.M. Sechenov First Moscow State Medical University, Department of Transplantology and Artificial Organs, MoscowBelatacept is a novel immunosuppressive agent that inhibits T-cell activation by blocking CD28 signaling pa- thway. It was developed based on abatacept (CTLA-4Ig), the first recombinant immunoglobulin fusion protein which contains extracellular part of CTLA-4 molecule and Fc domain of IgG. First clinical trials have shown the comparable patient and graft survival in group of kidney recipients with belatacept-based maintenance im- munosuppressive therapy versus Cyclosporin A-based therapy. Advantages observed with belatacept include superior glomerular filtration rate and improved cardiovascular risk profile. Belatacept is a potential option for maintenance immunosuppressive therapy without calcineurin inhibitors. Concerns associated with belatacept use are higher rates of acute cellular rejection episodes and post-transplant lymphoproliferative disorder cases.https://journal.transpl.ru/vtio/article/view/146kidney transplantationbelataceptctla-4 igcd28 |
| spellingShingle | A. I. Sushkov Y. G. Moysyuk BELATACEPT IN RENAL TRANSPLANTATION Vestnik Transplantologii i Iskusstvennyh Organov kidney transplantation belatacept ctla-4 ig cd28 |
| title | BELATACEPT IN RENAL TRANSPLANTATION |
| title_full | BELATACEPT IN RENAL TRANSPLANTATION |
| title_fullStr | BELATACEPT IN RENAL TRANSPLANTATION |
| title_full_unstemmed | BELATACEPT IN RENAL TRANSPLANTATION |
| title_short | BELATACEPT IN RENAL TRANSPLANTATION |
| title_sort | belatacept in renal transplantation |
| topic | kidney transplantation belatacept ctla-4 ig cd28 |
| url | https://journal.transpl.ru/vtio/article/view/146 |
| work_keys_str_mv | AT aisushkov belataceptinrenaltransplantation AT ygmoysyuk belataceptinrenaltransplantation |