Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neuro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00169/full |
| _version_ | 1811220550005030912 |
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| author | Marcia H. Ratner Vidhya Kumaresan David H. Farb |
| author_facet | Marcia H. Ratner Vidhya Kumaresan David H. Farb |
| author_sort | Marcia H. Ratner |
| collection | DOAJ |
| description | Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind. |
| first_indexed | 2024-04-12T07:44:52Z |
| format | Article |
| id | doaj.art-a3e2c81de730418a9fabff83cd06049a |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T07:44:52Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a3e2c81de730418a9fabff83cd06049a2022-12-22T03:41:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-04-011010.3389/fendo.2019.00169420770Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric DisordersMarcia H. RatnerVidhya KumaresanDavid H. FarbMemory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks across the life span of women and men point to a possible underlying pharmacological connectome by which these neuromodulators might act to modulate memory across diverse altered states of mind.https://www.frontiersin.org/article/10.3389/fendo.2019.00169/fullneurosteroidmemoryanxietydepressionschizophreniaallopregnanolone |
| spellingShingle | Marcia H. Ratner Vidhya Kumaresan David H. Farb Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders Frontiers in Endocrinology neurosteroid memory anxiety depression schizophrenia allopregnanolone |
| title | Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders |
| title_full | Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders |
| title_fullStr | Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders |
| title_full_unstemmed | Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders |
| title_short | Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders |
| title_sort | neurosteroid actions in memory and neurologic neuropsychiatric disorders |
| topic | neurosteroid memory anxiety depression schizophrenia allopregnanolone |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00169/full |
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