The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function
RNA binding proteins (RBPs) have a broad biological and physiological function and are critical in regulating pre-mRNA posttranscriptional processing, intracellular migration, and mRNA stability. QKI, also known as Quaking, is a member of the signal transduction and activation of RNA (STAR) family,...
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| Format: | Article |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.668659/full |
| _version_ | 1819014270469275648 |
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| author | Xinyun Chen Xinyun Chen Jianwen Yin Dayan Cao Deyong Xiao Zhongjun Zhou Ying Liu Weinian Shou |
| author_facet | Xinyun Chen Xinyun Chen Jianwen Yin Dayan Cao Deyong Xiao Zhongjun Zhou Ying Liu Weinian Shou |
| author_sort | Xinyun Chen |
| collection | DOAJ |
| description | RNA binding proteins (RBPs) have a broad biological and physiological function and are critical in regulating pre-mRNA posttranscriptional processing, intracellular migration, and mRNA stability. QKI, also known as Quaking, is a member of the signal transduction and activation of RNA (STAR) family, which also belongs to the heterogeneous nuclear ribonucleoprotein K- (hnRNP K-) homology domain protein family. There are three major alternatively spliced isoforms, QKI-5, QKI-6, and QKI-7, differing in carboxy-terminal domains. They share a common RNA binding property, but each isoform can regulate pre-mRNA splicing, transportation or stability differently in a unique cell type-specific manner. Previously, QKI has been known for its important role in contributing to neurological disorders. A series of recent work has further demonstrated that QKI has important roles in much broader biological systems, such as cardiovascular development, monocyte to macrophage differentiation, bone metabolism, and cancer progression. In this mini-review, we will focus on discussing the emerging roles of QKI in regulating cardiac and vascular development and function and its potential link to cardiovascular pathophysiology. |
| first_indexed | 2024-12-21T02:13:10Z |
| format | Article |
| id | doaj.art-a3e3558ded204ceabf89b582f914f1aa |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-21T02:13:10Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a3e3558ded204ceabf89b582f914f1aa2022-12-21T19:19:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.668659668659The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and FunctionXinyun Chen0Xinyun Chen1Jianwen Yin2Dayan Cao3Deyong Xiao4Zhongjun Zhou5Ying Liu6Weinian Shou7Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United StatesGuangdong Key Laboratory for Genome Stability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University, Shenzhen, ChinaDepartment of Foot, Ankle and Hand Surgery, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United StatesFaculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Hong KongDepartment of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, United StatesRNA binding proteins (RBPs) have a broad biological and physiological function and are critical in regulating pre-mRNA posttranscriptional processing, intracellular migration, and mRNA stability. QKI, also known as Quaking, is a member of the signal transduction and activation of RNA (STAR) family, which also belongs to the heterogeneous nuclear ribonucleoprotein K- (hnRNP K-) homology domain protein family. There are three major alternatively spliced isoforms, QKI-5, QKI-6, and QKI-7, differing in carboxy-terminal domains. They share a common RNA binding property, but each isoform can regulate pre-mRNA splicing, transportation or stability differently in a unique cell type-specific manner. Previously, QKI has been known for its important role in contributing to neurological disorders. A series of recent work has further demonstrated that QKI has important roles in much broader biological systems, such as cardiovascular development, monocyte to macrophage differentiation, bone metabolism, and cancer progression. In this mini-review, we will focus on discussing the emerging roles of QKI in regulating cardiac and vascular development and function and its potential link to cardiovascular pathophysiology.https://www.frontiersin.org/articles/10.3389/fcell.2021.668659/fullQKIpre-mRNA processingcardiovascular systemdevelopmentfunction |
| spellingShingle | Xinyun Chen Xinyun Chen Jianwen Yin Dayan Cao Deyong Xiao Zhongjun Zhou Ying Liu Weinian Shou The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function Frontiers in Cell and Developmental Biology QKI pre-mRNA processing cardiovascular system development function |
| title | The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function |
| title_full | The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function |
| title_fullStr | The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function |
| title_full_unstemmed | The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function |
| title_short | The Emerging Roles of the RNA Binding Protein QKI in Cardiovascular Development and Function |
| title_sort | emerging roles of the rna binding protein qki in cardiovascular development and function |
| topic | QKI pre-mRNA processing cardiovascular system development function |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.668659/full |
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