Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up
<i>Background and Objectives:</i> Interstitial lung diseases have always been an issue for pulmonary and rheumatology physicians. Computed tomography scans with a high-resolution protocol and bronchoalveolar lavage have been used along with biochemical blood tests to reach a diagnosis. &...
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/787 |
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| author | Paul Zarogoulidis Dimitris Matthaios Haidong Huang Chong Bai Wolfgang Hohenforst-Schmidt Konstantinos Porpodis Dimitris Petridis Konstantinos Pigakis Nikolaos Kougkas Panagoula Oikonomou Christina Nikolaou Dimitris Hatzibougias Chrysanthi Sardeli |
| author_facet | Paul Zarogoulidis Dimitris Matthaios Haidong Huang Chong Bai Wolfgang Hohenforst-Schmidt Konstantinos Porpodis Dimitris Petridis Konstantinos Pigakis Nikolaos Kougkas Panagoula Oikonomou Christina Nikolaou Dimitris Hatzibougias Chrysanthi Sardeli |
| author_sort | Paul Zarogoulidis |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Interstitial lung diseases have always been an issue for pulmonary and rheumatology physicians. Computed tomography scans with a high-resolution protocol and bronchoalveolar lavage have been used along with biochemical blood tests to reach a diagnosis. <i>Materials and Methods:</i> We included 80 patients in total. First, all patients had their diagnosis with computed tomography of the thorax, serological/ immunological blood tests and bronchoalveolar lavage. However; after 3 months, all were divided into 2 groups: those who had bronchoalveolar lavage again and those who had cryobiopsy instead of bronchoalveolar lavage (40/40). Positron emission-computed tomography was also performed upon the first and second diagnosis. The patients’ follow-up was 4 years from diagnosis. <i>Results:</i> Patients suffered most from chronic obstructive pulmonary disease (56, 70%), while lung cancer was rarely encountered in the sample (7, 9.75%). Age distribution ranged between 53 and 68 years with a mean value of 60 years. The computed tomography findings revealed 25 patients with typical diagnosis (35.2%), 17 with interstitial pulmonary fibrosis (23.9%) and 11 with probable diagnosis (11%). The cryobiopsy technique led to a new diagnosis in 28 patients (35% of the total sample). Patients who had a new diagnosis with cryobiopsy had a mean survival time of 710 days (<1460). Positron emission-computed tomography SUV uptake was positively associated with the cryobiopsy technique/new disease diagnosis and improved all respiratory functions. Discussion: Positron emission-computed tomography is a tool that can be used along with respiratory functions for disease evaluation. <i>Conclusions:</i> Cryobiopsy is a safe tool for patients with interstitial lung disease and can assist in the diagnosis of interstitial lung diseases. The survival of patients was increased in the cryobiopsy group versus only bronchoalveolar lavage for disease diagnosis. |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:45:53Z |
| publishDate | 2023-04-01 |
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| series | Medicina |
| spelling | doaj.art-a3e64ee0e8f34246b49ad97e17b76d1a2023-11-17T20:22:06ZengMDPI AGMedicina1010-660X1648-91442023-04-0159478710.3390/medicina59040787Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-UpPaul Zarogoulidis0Dimitris Matthaios1Haidong Huang2Chong Bai3Wolfgang Hohenforst-Schmidt4Konstantinos Porpodis5Dimitris Petridis6Konstantinos Pigakis7Nikolaos Kougkas8Panagoula Oikonomou9Christina Nikolaou10Dimitris Hatzibougias11Chrysanthi Sardeli12Pulmonary Department, General Clinic Euromedica, 54454 Thessaloniki, GreeceOncology Department, General Hospital of Rhodes, 85133 Rhodes, GreeceDepartment of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai 200433, ChinaDepartment of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai 200433, ChinaSana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, “Hof” Clinics, University of Erlangen, 91052 Hof, GermanyPulmonary Department, “George Papanikolaou” General Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, GreeceDepartment of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute, 57400 Thessaloniki, GreeceIntensive Care Unit, Creta Interclinic, 71304 Iraklio, GreeceRheumatology Department, Ippokrateio University General Hospital, 54642 Thessaloniki, GreeceSecond Department of Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreeceSecond Department of Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, GreecePrivate Pathology Lab., Microdiagnostics Ltd., 54622 Thessaloniki, GreeceDepartment of Pharmacology & Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece<i>Background and Objectives:</i> Interstitial lung diseases have always been an issue for pulmonary and rheumatology physicians. Computed tomography scans with a high-resolution protocol and bronchoalveolar lavage have been used along with biochemical blood tests to reach a diagnosis. <i>Materials and Methods:</i> We included 80 patients in total. First, all patients had their diagnosis with computed tomography of the thorax, serological/ immunological blood tests and bronchoalveolar lavage. However; after 3 months, all were divided into 2 groups: those who had bronchoalveolar lavage again and those who had cryobiopsy instead of bronchoalveolar lavage (40/40). Positron emission-computed tomography was also performed upon the first and second diagnosis. The patients’ follow-up was 4 years from diagnosis. <i>Results:</i> Patients suffered most from chronic obstructive pulmonary disease (56, 70%), while lung cancer was rarely encountered in the sample (7, 9.75%). Age distribution ranged between 53 and 68 years with a mean value of 60 years. The computed tomography findings revealed 25 patients with typical diagnosis (35.2%), 17 with interstitial pulmonary fibrosis (23.9%) and 11 with probable diagnosis (11%). The cryobiopsy technique led to a new diagnosis in 28 patients (35% of the total sample). Patients who had a new diagnosis with cryobiopsy had a mean survival time of 710 days (<1460). Positron emission-computed tomography SUV uptake was positively associated with the cryobiopsy technique/new disease diagnosis and improved all respiratory functions. Discussion: Positron emission-computed tomography is a tool that can be used along with respiratory functions for disease evaluation. <i>Conclusions:</i> Cryobiopsy is a safe tool for patients with interstitial lung disease and can assist in the diagnosis of interstitial lung diseases. The survival of patients was increased in the cryobiopsy group versus only bronchoalveolar lavage for disease diagnosis.https://www.mdpi.com/1648-9144/59/4/787cryobiopsyILDcomputed tomography scanpositron emission-computed tomographybronchoscopy |
| spellingShingle | Paul Zarogoulidis Dimitris Matthaios Haidong Huang Chong Bai Wolfgang Hohenforst-Schmidt Konstantinos Porpodis Dimitris Petridis Konstantinos Pigakis Nikolaos Kougkas Panagoula Oikonomou Christina Nikolaou Dimitris Hatzibougias Chrysanthi Sardeli Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up Medicina cryobiopsy ILD computed tomography scan positron emission-computed tomography bronchoscopy |
| title | Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up |
| title_full | Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up |
| title_fullStr | Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up |
| title_full_unstemmed | Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up |
| title_short | Positron Emission-Computed Tomography, Cryobiopsy versus Bronchoalveolar Lavage and Computed Tomography Findings for Interstitial Lung Disease: A Long-Term Follow-Up |
| title_sort | positron emission computed tomography cryobiopsy versus bronchoalveolar lavage and computed tomography findings for interstitial lung disease a long term follow up |
| topic | cryobiopsy ILD computed tomography scan positron emission-computed tomography bronchoscopy |
| url | https://www.mdpi.com/1648-9144/59/4/787 |
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