Effect of lipotoxicity on mitochondrial function and epigenetic programming during bovine in vitro embryo production

Abstract Maternal metabolic disorders may cause lipotoxic effects on the developing oocyte. Understanding the timing at which this might disrupt embryo epigenetic programming and how this is linked with mitochondrial dysfunction is crucial for improving assisted reproductive treatments, but has not...

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Bibliographic Details
Main Authors: Ben Meulders, Waleed F. A. Marei, Inne Xhonneux, Peter E. J. Bols, Jo L. M. R. Leroy
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-49184-0