Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products
Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/2/1337 |
| _version_ | 1818584940952944640 |
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| author | Markus Kaiser Sara C. Stolze |
| author_facet | Markus Kaiser Sara C. Stolze |
| author_sort | Markus Kaiser |
| collection | DOAJ |
| description | Cyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings. |
| first_indexed | 2024-12-16T08:29:10Z |
| format | Article |
| id | doaj.art-a3e68694315141a893149939a7e6f020 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T08:29:10Z |
| publishDate | 2013-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a3e68694315141a893149939a7e6f0202022-12-21T22:37:55ZengMDPI AGMolecules1420-30492013-01-011821337136710.3390/molecules18021337Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural ProductsMarkus KaiserSara C. StolzeCyclodepsipeptide natural products often display intriguing biological activities that along with their complex molecular scaffolds, makes them interesting targets for chemical synthesis. Although cyclodepsipeptides feature highly diverse chemical structures, their synthesis is often associated with similar synthetic challenges such as the establishment of a suitable macrocyclization methodology. This review therefore compiles case studies of synthetic approaches to different bioactive cyclodepsipeptide natural products, thereby illustrating obstacles of cyclodepsipeptide synthesis as well as their overcomings.http://www.mdpi.com/1420-3049/18/2/1337cyclodepsipeptidestotal synthesisnatural productsapratoxin AspiruchostatinFK228ramoplaninmicropeptin T-20Ahp-cyclodepsipeptidesymplocamide A |
| spellingShingle | Markus Kaiser Sara C. Stolze Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products Molecules cyclodepsipeptides total synthesis natural products apratoxin A spiruchostatin FK228 ramoplanin micropeptin T-20 Ahp-cyclodepsipeptide symplocamide A |
| title | Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products |
| title_full | Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products |
| title_fullStr | Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products |
| title_full_unstemmed | Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products |
| title_short | Case Studies of the Synthesis of Bioactive Cyclodepsipeptide Natural Products |
| title_sort | case studies of the synthesis of bioactive cyclodepsipeptide natural products |
| topic | cyclodepsipeptides total synthesis natural products apratoxin A spiruchostatin FK228 ramoplanin micropeptin T-20 Ahp-cyclodepsipeptide symplocamide A |
| url | http://www.mdpi.com/1420-3049/18/2/1337 |
| work_keys_str_mv | AT markuskaiser casestudiesofthesynthesisofbioactivecyclodepsipeptidenaturalproducts AT saracstolze casestudiesofthesynthesisofbioactivecyclodepsipeptidenaturalproducts |