Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil
Abstract Background Adolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-022-14134-4 |
| _version_ | 1818021596510552064 |
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| author | Leo Pedrana Laio Magno Eliana Miura Zucchi Luís Augusto Vasconcelos da Silva Dulce Ferraz Alexandre Grangeiro Marcelo Castellanos Sandra Assis Brasil Inês Dourado |
| author_facet | Leo Pedrana Laio Magno Eliana Miura Zucchi Luís Augusto Vasconcelos da Silva Dulce Ferraz Alexandre Grangeiro Marcelo Castellanos Sandra Assis Brasil Inês Dourado |
| author_sort | Leo Pedrana |
| collection | DOAJ |
| description | Abstract Background Adolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the Food and Drug Administration, their acceptability among aMSM/aTGW is not well known. Methods Forty-eight semi-structured interviews were conducted to assess the knowledge and interest in LAI-PrEP among aMSM/aTGW enrolled in a daily oral PrEP cohort from two capital cities of Brazil since 2019. Results Previous knowledge of LAI-PrEP remains scarce, but the high interest regarding its use has been reported. Interest in the use of LAI-PrEP is associated with eliminating the burden of daily responsibility or the risk of missing the necessary medications, lowering the costs of this method, increasing confidentiality, and decreasing the frequency of visiting PrEP clinics. The reported barriers to uptake included fear of injection, doubts on its effectiveness, side effects, and greater dependence on a health provider. Conclusions There is an urgent need to strengthen the preventive strategies against HIV infection among the youth, enhance their knowledge and those of healthcare providers, and offer safe and new options. |
| first_indexed | 2024-04-14T08:20:17Z |
| format | Article |
| id | doaj.art-a3e7914ad3eb4101bb66437944316cf1 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-14T08:20:17Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-a3e7914ad3eb4101bb66437944316cf12022-12-22T02:04:14ZengBMCBMC Public Health1471-24582022-09-0122111010.1186/s12889-022-14134-4Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in BrazilLeo Pedrana0Laio Magno1Eliana Miura Zucchi2Luís Augusto Vasconcelos da Silva3Dulce Ferraz4Alexandre Grangeiro5Marcelo Castellanos6Sandra Assis Brasil7Inês Dourado8Instituto de Saúde Coletiva, Universidade Federal da BahiaInstituto de Saúde Coletiva, Universidade Federal da BahiaPrograma de Pós-Graduação em Saúde Coletiva, Mestrado Profissional em Psicologia, Desenvolvimento e Políticas Públicas, Universidade Católica de SantosInstituto de Humanidades, Artes e Ciências, Universidade Federal da BahiaFIOCRUZ Escola do Governo, Fundação Oswaldo CruzFaculdade de Medicina da Universidade de São PauloInstituto de Saúde Coletiva, Universidade Federal da BahiaDepartmento de Ciências da Vida, Universidade Estadual da BahiaInstituto de Saúde Coletiva, Universidade Federal da BahiaAbstract Background Adolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the Food and Drug Administration, their acceptability among aMSM/aTGW is not well known. Methods Forty-eight semi-structured interviews were conducted to assess the knowledge and interest in LAI-PrEP among aMSM/aTGW enrolled in a daily oral PrEP cohort from two capital cities of Brazil since 2019. Results Previous knowledge of LAI-PrEP remains scarce, but the high interest regarding its use has been reported. Interest in the use of LAI-PrEP is associated with eliminating the burden of daily responsibility or the risk of missing the necessary medications, lowering the costs of this method, increasing confidentiality, and decreasing the frequency of visiting PrEP clinics. The reported barriers to uptake included fear of injection, doubts on its effectiveness, side effects, and greater dependence on a health provider. Conclusions There is an urgent need to strengthen the preventive strategies against HIV infection among the youth, enhance their knowledge and those of healthcare providers, and offer safe and new options.https://doi.org/10.1186/s12889-022-14134-4Pre-exposure prophylaxisLong-acting injectableAcceptabilityAdolescentsHIV/AIDS |
| spellingShingle | Leo Pedrana Laio Magno Eliana Miura Zucchi Luís Augusto Vasconcelos da Silva Dulce Ferraz Alexandre Grangeiro Marcelo Castellanos Sandra Assis Brasil Inês Dourado Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil BMC Public Health Pre-exposure prophylaxis Long-acting injectable Acceptability Adolescents HIV/AIDS |
| title | Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil |
| title_full | Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil |
| title_fullStr | Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil |
| title_full_unstemmed | Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil |
| title_short | Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil |
| title_sort | zero knowledge and high interest in the use of long acting injectable pre exposure prophylaxis prep among adolescent men who have sex with men and transgender women in two capital cities in brazil |
| topic | Pre-exposure prophylaxis Long-acting injectable Acceptability Adolescents HIV/AIDS |
| url | https://doi.org/10.1186/s12889-022-14134-4 |
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