Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Abstract Background In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 receptor-associated kinase 4 small molecule inhibitor (IRAK4i) affects RNA-IC...

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Bibliographic Details
Main Authors: Karin Hjorton, Niklas Hagberg, Elisabeth Israelsson, Lisa Jinton, Olof Berggren, Johanna K. Sandling, Kristofer Thörn, John Mo, The DISSECT consortium, Maija-Leena Eloranta, Lars Rönnblom
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Arthritis Research & Therapy
Subjects:
SLE
pDC
NK
HCQ
IRAK4
Online Access:http://link.springer.com/article/10.1186/s13075-018-1702-0

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